F0604 | Mitochondrial protein translation

GO:0032543 R-HSA-5368287
Mitochondrial DNA >> mitochondrial protein translation

Compound Dose Time Species Model Method Action Result Positive criterion Reference
tetracyclines decrease Positive 307
Zidovudine decrease Positive 307
Acyclovir decrease Positive 307
Ganciclovir decrease Positive 307
Zalcitabine decrease Positive 307
Linezolid 16 ± 2 μM Isolated rat heart mitochondria Mitochondrial protein synthesis (MPS) assay with [35S]methionine Positive IC50 282
eperezolid 9.5 ± 1.5 μM Isolated rat heart mitochondria Mitochondrial protein synthesis (MPS) assay with [35S]methionine Positive IC50 282
eperezolid 4.2 ± 0.4 μM rat Isolated liver mitochondria Mitochondrial protein synthesis assay (The incorporation of [35S]methionine into mitochondrial protein was determined by a filter paper disk assay ) Positive IC50 281
Chloramphenicol 9.8 ± 0.5 μM rat liver mitochondria Mitochondrial protein synthesis assay (The incorporation of [35S]methionine into mitochondrial protein was determined by a filter paper disk assay ) Positive IC50 281
tetracyclines 2.1 ± 0.5 μM rat liver mitochondria Mitochondrial protein synthesis assay (The incorporation of [35S]methionine into mitochondrial protein was determined by a filter paper disk assay ) Positive IC50 281
Linezolid 12.8 ± 2.8 μM rat liver mitochondria Mitochondrial protein synthesis assay (The incorporation of [35S]methionine into mitochondrial protein was determined by a filter paper disk assay ) Positive IC50 281
Linezolid haplo-insufficiency profiling (HIP), a well-validated chemical genomics platform developed in the yeast S. Cerevisiae. inhibitor Positive 288
doxycycline 143B osteosarcoma cells inhibitor Positive 285
Chloramphenicol haplo-insufficiency profiling (HIP), a well-validated chemical genomics platform developed in the yeast S. Cerevisiae. inhibitor Positive 288
Linezolid Positive 197
tigecycline haplo-insufficiency profiling (HIP), a well-validated chemical genomics platform developed in the yeast S. Cerevisiae. inhibitor Positive 288
tigecycline 2.5-10μM 48hr TEX, OCI-AML2, and two AML patients' cells weatern blot (protein levels of Cox-1, Cox-2, Cox-4, Grp78, XIAP, Actin, and tubulin) inhibitor Positive 288