MITOTOX

Drug

D1417 | tigecycline

Molecular Formula	C29H39N5O8
Molecular Weight	585.6
Structure
State	solid
Protein binding	71% to 89%
Half life	27-43 hours
Trade names	Tygacil
Description	tetracycline antibiotic; glycylcycline;

J01AA20 Combinations of tetracyclines

[J01AA] Tetracyclines

[J01A] TETRACYCLINES

[J01] ANTIBACTERIALS FOR SYSTEMIC USE

[J] Antiinfectives for systemic use

J01AA12 Tigecycline

[J01AA] Tetracyclines

[J01A] TETRACYCLINES

[J01] ANTIBACTERIALS FOR SYSTEMIC USE

[J] Antiinfectives for systemic use

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
MITOCHONDRIAL PROTEIN TRANSLATION					haplo-insufficiency profiling (HIP), a well-validated chemical genomics platform developed in the yeast S. Cerevisiae.	inhibitor		288
MITOCHONDRIAL PROTEIN TRANSLATION	2.5-10μM	48hr		TEX, OCI-AML2, and two AML patients' cells	weatern blot (protein levels of Cox-1, Cox-2, Cox-4, Grp78, XIAP, Actin, and tubulin)	inhibitor		288