MITOTOX

Compound

D1418 | 3-morpholinosydnonimine

Properties

Molecular Formula	C26H29Cl2N3
Molecular Weight	454.4
Structure
Description	metabolite of molsidomine which decomposes spontaneously in solution in the presence of oxygen, releasing NO and superoxide anion; Since NO and superoxide react to form peroxynitrite, SIN-1 may actually produce peroxynitrite under physiological conditions.

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
GLUTATHIONE METABOLISM	150 μM	24 hr	rat	PC12 cells	The total glutathione (reduced form GSH + oxidized form GSSG) was determined using glutathione reductase	restore GSH		289
ROS PRODUCTION	150 μM	24 hr	rat	PC12 cells	Measurement of intracellular ROS formation with DCFH2-DA	decrease		289

Indications Source: SIDER

Synonyms Source: PubChem

SIN-1, Linsidomine

External IDs

CAS Number	16142-27-1
PubChem Compound	24278580

References