MITOTOX

Drug

D1424 | brequinar sodium

Molecular Formula	C23H14F2NNaO2
Molecular Weight	397.3
Structure
State	solid
Description	an inhibitor of DHODH activity that also binds to the ubiquinone binding site; blocking de novo pyrimidine biosynthesis

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
ELONGATION	1 μM	48hr		C2C12 cells		induce		295

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
Dihydroorotate dehydrogenase	1 μM	48hr		C2C12 cells		inhibit		295