T251 Source: Uniprot

enzymeDihydroorotate dehydrogenase (DHOdehase)
Full Name Dihydroorotate dehydrogenase
Protein Names Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC (Dihydroorotate oxidase)
Subcellular Location Mitochondrion inner membrane Single-pass membrane protein
EC numbers
Uniprot Accession Q02127
Uniprot Name PYRD_HUMAN
Gene symbol DHODH
Gene Name Dihydroorotate dehydrogenase (quinone)
Ensembl ENSG00000102967

Compound Dose Time Species Model Method Result Positive criterion Reference
Teriflunomide Positive 295
Leflunomide 50 μM 48 hr HeLa cells, C2C12 muscle cells, MEF cells Mfn2 and Mfn1 mRNA levels; MFN2, MFN1, and porin protein levels; images of mitochondrial morphology ; Positive 295
brequinar sodium 1 μM 48hr C2C12 cells Positive 295