F030803 | Fusion

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Teriflunomide induce Positive 295
Leflunomide 50 μM 48 hr HeLa cells, C2C12 muscle cells, MEF cells Mfn2 and Mfn1 mRNA levels; MFN2, MFN1, and porin protein levels; images of mitochondrial morphology ; induce Positive 295
colchicine Positive 185
docetaxel Positive 185
BGP-15 50 μM 4hr WRL-68 cells Polyethylene glycol (PEG) fusion assay; OPA1 GTPase assay and OPA1-OPA1 interactions induce Positive 297