Drug
D1434 | Maprotiline
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| OPENING OF PERMEABILITY TRANSITION PORE (PTP) | 5 µM | 1 hour | Human | HepG2 | High-content screening assay | Decrease | MEC | 306 |
| MEMBRANE POTENTIAL | 5 µM | 1 hour | Human | HepG2 | High-content screening assay | Decrease | MEC | 306 |
| ROS PRODUCTION | 5 µM | 1 hour | Human | HepG2 | High-content screening assay | Increase | MEC | 306 |
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Reactive oxygen species | 5 µM | 1 hour | Human | HepG2 | High-content screening assay | increase | MEC | 306 |