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F020301 | Generation of citrate

GO:0006101 map00020 R-HSA-71403
Function of mitochondria >> TCA >> generation of citrate

Compound Dose Time Species Model Method Action Result Positive criterion Reference
Metformin 0.5mM 24 hours human MCF10A Meassurement of citrate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 0.5mM 24 hours human MCF7 Meassurement of citrate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 5mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Meassurement of citrate concentration; compared with MCF10A affect Positive p < 0.05 172
Metformin 5mM 30 minutes mouse; C57BL/6J isolated skeletal muscle mitochondria Meassurement of citrate concentration; compared with MCF10A affect Positive p < 0.05 172

T106. citrate