F020303 | Generation of alpha-ketoglutarate
GO:0006103
map00020
R-HSA-71403
Function of mitochondria >> TCA >> generation of alpha-ketoglutarate
Function of mitochondria >> TCA >> generation of alpha-ketoglutarate
| Compound | Dose | Time | Species | Model | Method | Action | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Metformin | 5mM | 30 minutes | mouse; C57BL/6J | isolated skeletal muscle mitochondria | Meassurement of alpha-ketoglutarate concentration; compared with MCF10A | affect | Positive | p < 0.05 | 172 |
| Metformin | 5mM | 30 minutes | mouse; C57BL/6J | isolated skeletal muscle mitochondria | Meassurement of alpha-ketoglutarate concentration; compared with MCF10A | affect | Positive | p < 0.05 | 172 |
| Metformin | 0.5mM | 24 hours | human | MCF10A | Meassurement of alpha-ketoglutarate concentration; compared with MCF10A | affect | Positive | p < 0.05 | 172 |
| Metformin | 0.5mM | 24 hours | human | MCF7 | Meassurement of alpha-ketoglutarate concentration; compared with MCF10A | affect | Positive | p < 0.05 | 172 |