F021214 | NADH level
| Compound | Dose | Time | Species | Model | Method | Action | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Gentamicin | 300 μg/ml | 1hr | postnatal day 6 (P6±1d) FVB mice | basal turn outer hair cells ( low-frequency processing OHCs) from intact cochlear (organ of Corti) explants | scanning confocal microscope (NADH autofluorescence); T1 imaging buffer contained 5 mM glucose. T2 imaging buffer contained 10 mM glucose, 3 mM glutamate and 2 mM pyruvate. | decrease | Positive | 312 | |