F0603 | Mitochondrial RNA processing
Mitochondrial DNA >> mitochondrial RNA processing
| Compound | Dose | Time | Species | Model | Method | Action | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|---|
| LDC203974 | 10 μM | 6hr | HeLa cells | Mitochondrial transcript levels of ND1 and CYTB | inhibit | Positive | 314 | ||
| LDC203974 | 0–10 μM | Single nucleotide incorporation assays at varying ATP concentrations | inhibit | Positive | Vmax app, maximum reaction rate; Km app, substrate affinity | 314 | |||
| LDC203974 | 743nM | Microscale thermophoresis binding curves in the absence or presence of 10 μM IMT1B | inhibit | Positive | Kd | 314 | |||