F0603 | Mitochondrial RNA processing


Mitochondrial DNA >> mitochondrial RNA processing

Compound Dose Time Species Model Method Action Result Positive criterion Reference
LDC203974 10 μM 6hr HeLa cells Mitochondrial transcript levels of ND1 and CYTB inhibit Positive 314
LDC203974 0–10 μM Single nucleotide incorporation assays at varying ATP concentrations inhibit Positive Vmax app, maximum reaction rate; Km app, substrate affinity 314
LDC203974 743nM Microscale thermophoresis binding curves in the absence or presence of 10 μM IMT1B inhibit Positive Kd 314