Compound | Dose | Time | Species | Model | Method | Action | Result | Positive criterion | Reference |
---|---|---|---|---|---|---|---|---|---|
Clotrimazole | 30 μmol/L | 24 hours | human | CAL27 | Apoptosis measurement | increase | Positive | p < 0.05 | 5 |
Clotrimazole | 30 μmol/L | 24 hours | human | SCC25 | Apoptosis measurement | increase | Positive | p < 0.05 | 5 |
Clotrimazole | 30 μmol/L | 24 hours | human | UM1 | Apoptosis measurement | increase | Positive | p < 0.05 | 5 |
Clotrimazole | 40 μmol/L | 24 hours | human | CAL27 | Apoptosis measurement | increase | Positive | p < 0.01 | 5 |
Clotrimazole | 40 μmol/L | 24 hours | human | SCC25 | Apoptosis measurement | increase | Positive | p < 0.01 | 5 |
Clotrimazole | 40 μmol/L | 24 hours | human | UM1 | Apoptosis measurement | increase | Positive | p < 0.01 | 5 |