T026 Source: Uniprot
enzyme3-ketoacyl-CoA thiolase, mitochondrial
(Beta-ketothiolase)
Transferase
Hydrolase
Acyltransferase
| Full Name | 3-ketoacyl-CoA thiolase, mitochondrial |
|---|---|
| Protein Names | 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-) (EC 3.1.2.1) (EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1) |
| Subcellular Location | Mitochondrion |
| EC numbers | 2.3.1.16; 2.3.1.9; 3.1.2.-; 3.1.2.1; 3.1.2.2 |
| Uniprot Accession | P42765 |
| Uniprot Name | THIM_HUMAN |
| Gene symbol | ACAA2 |
| Gene Name | Acetyl-CoA acyltransferase 2 |
| Ensembl | ENSG00000167315 |
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| benzarone | 100 μmol/L | rat; Sprague–Dawley | liver mitochondria | Measurement of β‐ketothiolase activity | Positive | 11% inhibition | 4 | |
| benzbromarone | 100 μmol/L | rat; Sprague–Dawley | liver mitochondria | Measurement of β‐ketothiolase activity | Positive | 25% inhibition | 4 | |
| Amiodarone | 100 μmol/L | rat; Sprague–Dawley | liver mitochondria | Measurement of β‐ketothiolase activity | Negative | no inhibition | 4 | |
| 2‐Butylbenzofuran | 100 μmol/L | rat; Sprague–Dawley | liver mitochondria | Measurement of β‐ketothiolase activity | Negative | no inhibition | 4 | |