T032 Source: Uniprot
enzymeShort/branched chain specific acyl-CoA dehydrogenase, mitochondrial
(SBCAD)
Oxidoreductase
| Full Name | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial |
|---|---|
| Protein Names | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (SBCAD) (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase) |
| Subcellular Location | Mitochondrion matrix |
| EC numbers | 1.3.8.5 |
| Uniprot Accession | P45954 |
| Uniprot Name | ACDSB_HUMAN |
| Gene symbol | ACADSB |
| Gene Name | Acyl-CoA dehydrogenase short/branched chain |
| Ensembl | ENSG00000196177 |
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Amiodarone | 100 μmol/L | rat; Sprague–Dawley | liver mitochondria | Measurement of acyl‐CoA dehydrogenase activity | Positive | 28% inhibition | 4 | |
| benzarone | 100 μmol/L | rat; Sprague–Dawley | liver mitochondria | Measurement of acyl‐CoA dehydrogenase activity | Positive | 33% inhibition | 4 | |
| benzbromarone | 100 μmol/L | rat; Sprague–Dawley | liver mitochondria | Measurement of acyl‐CoA dehydrogenase activity | Positive | 34% inhibition | 4 | |
| 2‐Butylbenzofuran | 100 μmol/L | rat; Sprague–Dawley | liver mitochondria | Measurement of acyl‐CoA dehydrogenase activity | Positive | 22% inhibition | 4 | |