Compound	Dose	Time	Species	Model	Method	Result	Positive criterion	Reference
Metformin	5mM	30 minutes	mouse; C57BL/6J	isolated skeletal muscle mitochondria	Meassurement of alpha-ketoglutarate concentration; compared with MCF10A	Positive	p < 0.05	172
Metformin	5mM	30 minutes	mouse; C57BL/6J	isolated skeletal muscle mitochondria	Meassurement of alpha-ketoglutarate concentration; compared with MCF10A	Positive	p < 0.05	172
Metformin	0.5mM	24 hours	human	MCF10A	Meassurement of alpha-ketoglutarate concentration; compared with MCF10A	Positive	p < 0.05	172
Metformin	0.5mM	24 hours	human	MCF7	Meassurement of alpha-ketoglutarate concentration; compared with MCF10A	Positive	p < 0.05	172

F020303. generation of alpha-ketoglutarate
F0203. TCA