T208 Source: Uniprot
proteinmitochondrial KATP chanel (mtKATP)
(mKATP)
Ion channel
| Full Name | mitochondrial KATP chanel (mtKATP) |
|---|---|
| Protein Names | Mitochondrial potassium channel ATP-binding subunit (ATP-binding cassette sub-family B member 8, mitochondrial) (ABCB8) (Mitochondrial ATP-binding cassette 1) (M-ABC1) (Mitochondrial sulfonylurea-receptor) (MITOSUR) |
| Subcellular Location | Mitochondrion inner membrane Multi-pass membrane protein |
| Uniprot Accession | Q9NUT2 |
| Uniprot Name | MITOS_HUMAN |
| Gene symbol | ABCB8 |
| Gene Name | ATP binding cassette subfamily B member 8 |
| Ensembl | ENSG00000197150 |
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Diazoxide | EC50= 40mmol/L, saturation by 100mmol/L | Primary Culture of Neonatal Rat Cardiac Ventricular Myocytes | flow cytometry and quantitative image analysis of cells stained with fluorescent DC indicators. | Positive | 188 | |||
| Pinacidil | Positive | 188 | ||||||
| 5-Hydroxydecanoate | 500mmol/L | Primary Culture of Neonatal Rat Cardiac Ventricular Myocytes | flow cytometry and quantitative image analysis of cells stained with fluorescent DC indicators. | Positive | 188 | |||
| Glibenclamide | Positive | 188 | ||||||
| Glibenclamide | K1/2 values 1-6 microM | heart and liver mitochondria from rat | Positive | 190 | ||||