T416 Source: Uniprot

enzymeSerine/threonine-protein kinase mTOR (mTOR)
Transferase Serine/threonine-protein kinase Kinase
Full Name Serine/threonine-protein kinase mTOR
Protein Names Serine/threonine-protein kinase mTOR (EC (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Subcellular Location Cytoplasm Cytoplasmic side Endoplasmic reticulum membrane Golgi apparatus membrane Lysosome Lysosome membrane Microsome membrane Mitochondrion outer membrane Nucleus, PML body Peripheral membrane protein
EC numbers
Uniprot Accession P42345
Uniprot Name MTOR_HUMAN
Gene symbol MTOR
Gene Name Mechanistic target of rapamycin kinase
Ensembl ENSG00000198793

Compound Dose Time Species Model Method Result Positive criterion Reference
rapamycin 200 nM Positive 252
Bafilomycin A1 Positive 200
everolimus Positive 266
rapamycin mouse embryonic retinas Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye Positive 252