Drug
D0119 | Thioridazine
N
N05AC02 Thioridazine
[N05AC] Phenothiazines with piperidine structure
[N05A] ANTIPSYCHOTICS
[N05] PSYCHOLEPTICS
[N] Nervous system
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| OPENING OF PERMEABILITY TRANSITION PORE (PTP) | increase | 49 | ||||||
| ELECTRON TRANSPORT CHAIN | rat | isolated liver mitochondria | Negative | 23 | ||||
| GLUCOSE GALACTOSE IC50 RATIO | 31.0 ± 5.9, 27.7 ± 19.8 ,1.4, 24.4 ± 5.7, 21.9 ± 18.0, 1.6 | 4hr | H9c2 cells | high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). | glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) | 50 | ||
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| NADH:ubiquinone reductase | rat | isolated liver mitochondria | Negative | 23 | ||||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
  |
Warning |
Aggregated GHS information provided by 195 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (99.49%): Harmful if swallowed [Warning Acute toxicity, oral] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (99.49%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P273, P301+P312, P330, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | intravenous | 71mg/kg (71mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972. | |
| mouse | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | National Technical Information Service. Vol. AD277-689, | |
| women | TDLo | oral | 864mg/kg/18D- (864mg/kg) | Postgraduate Medical Journal. Vol. 60, Pg. 445, 1984. | |
| rabbit | LD50 | oral | 1100mg/kg (1100mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972. | |
| mouse | LD50 | intravenous | 33mg/kg (33mg/kg) | Therapie. Vol. 14, Pg. 793, 1959. | |
| mouse | LD50 | oral | 360mg/kg (360mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972. | |
| rabbit | LD50 | intravenous | 26mg/kg (26mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972. | |
| rat | LD50 | oral | 1060mg/kg (1060mg/kg) | Drugs in Japan Vol. 6, Pg. 458, 1982. | |
| dog | LD50 | oral | 160mg/kg (160mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972. | |
| (+-)-Thioridazine | (.+/-.)-Thioridazine | (Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine |
| 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine | 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine | 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine |
| 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine # | 10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine (thioridazine) | 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfanyl-phenothiazine |
| 10-[2-(1-methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10h-phenothiazine | 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine | 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylthio)-10H-phenothiazine |
| 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine | 10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylthio)- | 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)- |
| 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylthio- | 1452-EP2272537A2 | 1452-EP2275420A1 |
| 1452-EP2298776A1 | 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine | 242T875 |
| 3-Methylmercapto-N-(2'-(N-methyl-2-piperidyl)ethyl)phenothiazine | 50-52-2 | 6960AB |
| AB00053553 | AB00053553-16 | AB00053553_17 |
| AB00053553_18 | AI3-51923 | API0003283 |
| AX8153985 | BCP19922 | BDBM50002338 |
| BPBio1_000325 | BPBio1_001175 | BRD-A84481105-003-17-2 |
| BSPBio_000295 | BSPBio_002030 | Biomol-NT_000017 |
| C21H26N2S2 | CAS-50-52-2 | CCG-205326 |
| CHEBI:9566 | CHEMBL479 | D00373 |
| DB00679 | DSSTox_CID_3656 | DSSTox_GSID_23656 |
| DSSTox_RID_77130 | DTXSID6023656 | DivK1c_000066 |
| EINECS 200-044-2 | GTPL100 | HMS2090J04 |
| HSDB 3189 | IDI1_000066 | KBio1_000066 |
| KBio2_001546 | KBio2_002308 | KBio2_004114 |
| KBio2_004876 | KBio2_006682 | KBio2_007444 |
| KBio3_001530 | KBio3_002788 | KBioGR_000791 |
| KBioGR_002308 | KBioSS_001546 | KBioSS_002310 |
| KLBQZWRITKRQQV-UHFFFAOYSA-N | L001321 | LS-105605 |
| Lopac0_001252 | MCULE-7796139302 | Mallorol |
| Malloryl | Meleril | Mellaril |
| Mellaril (*Hydrochloride*) | Mellaril (Salt/Mix) | Mellaril-S |
| Mellaril-S (TN) | Mellarit | Mellerets |
| Mellerette | Melleretten | Melleril |
| Melleril (liquid) | Melleryl | NCGC00016059-03 |
| NCGC00016059-04 | NCGC00016059-05 | NCGC00016059-07 |
| NCGC00016059-08 | NCGC00016059-09 | NCGC00016059-10 |
| NCGC00016059-11 | NCGC00016059-13 | NCGC00016059-14 |
| NCGC00089809-02 | NCGC00089809-03 | NINDS_000066 |
| NS-835 | NSC186060 | Orsanil |
| Phenothiazine, 10-((1-methyl-2-piperidyl)ethyl)-2-(methylthio)- | Phenothiazine, 10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylthio)- | Prestwick0_000078 |
| Prestwick1_000078 | Prestwick2_000078 | Prestwick3_000078 |
| Q58375 | SBI-0051219.P004 | SC-19270 |
| SCHEMBL12434241 | SCHEMBL9566 | SPBio_001483 |
| SPBio_002216 | Sonapax | Spectrum2_001332 |
| Spectrum3_000585 | Spectrum4_000356 | Spectrum5_001062 |
| Spectrum_001066 | TP-21 | Thioridazin |
| Thioridazine (USP/INN) | Thioridazine [USAN:INN:BAN] | Thioridazine [USAN:USP:INN:BAN] |
| Thioridazine prolongatum | Thioridazine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material | Thioridazine, prolongatum |
| Thioridazinum | Thioridazinum [INN-Latin] | Thioxidazine |
| Thiozine | Tioridazina | Tioridazina [INN-Spanish] |
| Tox21_110294 | Tox21_110294_1 | cMAP_000015 |
| dl-Thioridazine | thioridazine |
| DrugBank Name | Thioridazine |
| DrugBank | DB00679 |
| CAS Number | 107388-89-6, 130-61-0, 50-52-2 |
| PubChem Compound | 5452 |
| KEGG Drug | D00373 |
| PubChem.Substance | 46509070 |
| ChEBI | 9566 |
| PharmGKB | PA451666 |
| ChemSpider | 5253 |
| BindingDB | 50002338.0 |
| TTD | DAP000476 |
| Wikipedia | Thioridazine |
| DPD | 7962|7964 |
1. Dykens et al. (2007)