D0129 | 2,4-dinitrophenol
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| UNCOUPLING | increase | 24 | ||||||
| UNCOUPLING | increase | 35 | ||||||
| UNCOUPLING | 1.6e-6M | Mitochondria from several sources: mouse liver, rat liver, beef heart, | delta 02, delta G-6-P, P/O (with Succinate) | increase | 221 | |||
| UNCOUPLING | 0.002M | phosphorylating particles from Alcaligenes faecalis contain a coupling enzyme or enzymes bound to the DPNH oxidase particles by magnesium ion and a specific oligoribonucleotide | increase | 222 | ||||
| NONPROTONOPHORIC UNCOUPLERS | rat | liver mitochondria | RST assay( Respiratory Screening Technology)-measurement of oxygen consumption in isolated mitochondria using a phosphorescent oxygen-sensitive probe A65N-1 | affect | 204 | |||
| BASAL RESPIRATION | 0.5 μM / 6 hpf | zebrafish | XFe24 Extracellular Flux Analyzer | increase | 90 | |||
| BASAL RESPIRATION | 0.5 μM / 24 hpf | zebrafish | XFe24 Extracellular Flux Analyzer | Negative | 90 | |||
| BASAL RESPIRATION | 0.5 μM / 48 hpf | zebrafish | XFe24 Extracellular Flux Analyzer | decrease | 90 | |||
| BASAL RESPIRATION | 0.5 μM / 24 hpf | zebrafish | XFe24 Extracellular Flux Analyzer | affect | 90 | |||
| BASAL RESPIRATION | 0.5 μM / 48 hpf | zebrafish | XFe24 Extracellular Flux Analyzer | decrease | 90 | |||
| MAXIMAL RESPIRATION | 0.5 μM / 24 hpf | zebrafish | XFe24 Extracellular Flux Analyzer | decrease | 90 | |||
| SPARE/ RESPIRATORY CAPACITY | 0.5 μM / 24 hpf | zebrafish | XFe24 Extracellular Flux Analyzer | increase | 90 | |||
| PROTON LEAK | 0.5 μM / 24 hpf | zebrafish | XFe24 Extracellular Flux Analyzer | decrease | 90 | |||
| GLYCOLYSIS | increase | 24 | ||||||
| GLUCOSE GALACTOSE IC50 RATIO | 2.1 | LUHMES (Lund human mesencephalic) cells | Glc–Gal–NeuriTox assay | Negative | EC25(NA) [Glc/Gal] | 326 | ||
| ACCUMULATION OF POTASSIUM | increase | 24 | ||||||
| ACCUMULATION OF PHOSPHATE | increase | 24 | ||||||
| MITOCHONDRIAL DYNAMICS | 50 μM DNP at 3 hours post fertilization (hpf) | Danio rerio | 247 | |||||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
   |
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H311: Toxic in contact with skin [Danger Acute toxicity, dermal] H331: Toxic if inhaled [Danger Acute toxicity, inhalation] H373 **: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] |
P260, P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P304+P340, P311, P312, P314, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
 |
Danger |
Aggregated GHS information provided by 74 companies from 4 notifications to the ECHA C&L Inventory. Reported as not meeting GHS hazard criteria by 38 of 74 companies. For more detailed information, please visit ECHA C&L website Of the 2 notification(s) provided by 36 of 74 companies with hazard statement code(s): H314 (91.67%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
Aggregated GHS information provided by 187 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301 (96.79%): Toxic if swallowed [Danger Acute toxicity, oral] H311 (99.47%): Toxic in contact with skin [Danger Acute toxicity, dermal] H331 (98.93%): Toxic if inhaled [Danger Acute toxicity, inhalation] H373 (99.47%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P304+P340, P311, P312, P314, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H311: Toxic in contact with skin [Danger Acute toxicity, dermal] H331: Toxic if inhaled [Danger Acute toxicity, inhalation] H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] |
P260, P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P304+P340, P311, P312, P314, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
  |
Danger |
H201: Explosive mass explosion hazard [Danger Explosives] H300: Fatal if swallowed [Danger Acute toxicity, oral] H310: Fatal in contact with skin [Danger Acute toxicity, dermal] H315: Causes skin irritation [Warning Skin corrosion/irritation] H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity] H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity] H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] |
P201, P202, P210, P230, P240, P250, P260, P262, P264, P270, P280, P281, P301+P310, P302+P350, P302+P352, P307+P311, P308+P313, P310, P314, P321, P322, P330, P332+P313, P361, P362, P363, P370+P380, P372, P373, P401, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Warning |
H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P273, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| pigeon | LDLo | intramuscular | 15mg/kg (15mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 187, 1933. | |
| dog | LDLo | subcutaneous | 20mg/kg (20mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 187, 1933. | |
| cat | LDLo | intramuscular | 25mg/kg (25mg/kg) | vascular: bp elevation not characterized in autonomic section | Journal of Pharmacology and Experimental Therapeutics. Vol. 48, Pg. 410, 1933. |
| guinea pig | LD50 | intraperitoneal | 28mg/kg (28mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 381, 1958. | |
| guinea pig | LDLo | skin | 700mg/kg (700mg/kg) | Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 10, 1948. | |
| rat | LD50 | subcutaneous | 25mg/kg (25mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 187, 1933. | |
| rabbit | LDLo | intramuscular | 20mg/kg (20mg/kg) | lungs, thorax, or respiration: respiratory stimulation | Journal of Pharmacology and Experimental Therapeutics. Vol. 48, Pg. 410, 1933. |
| mammal (species unspecified) | LD50 | unreported | 40mg/kg (40mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 97, 1971. | |
| pigeon | LD50 | intramuscular | 6500ug/kg (6.5mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 53, Pg. 58, 1935. | |
| bird - wild | LD50 | oral | 13mg/kg (13mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
| mouse | LD50 | intravenous | 56mg/kg (56mg/kg) | Toxicology and Applied Pharmacology. Vol. 6, Pg. 232, 1964. | |
| rabbit | LDLo | subcutaneous | 60mg/kg (60mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 187, 1933. | |
| guinea pig | LD50 | oral | 81mg/kg (81mg/kg) | Farmakologiya i Toksikologiya Vol. 28, Pg. 493, 1965. | |
| rabbit | LDLo | subcutaneous | 20mg/kg (20mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 187, 1933. | |
| guinea pig | LDLo | subcutaneous | 25mg/kg (25mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 192, Pg. 331, 1939. | |
| rat | LDLo | subcutaneous | 15mg/kg (15mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 48, Pg. 410, 1933. | |
| rabbit | LD50 | oral | 30mg/kg (30mg/kg) | Farmakologiya i Toksikologiya Vol. 28, Pg. 493, 1965. | |
| dog | LDLo | intravenous | 15mg/kg (15mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 187, 1933. | |
| pigeon | LDLo | intravenous | 15mg/kg (15mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 50, Pg. 20, 1935. | |
| dog | LDLo | subcutaneous | 25mg/kg (25mg/kg) | vascular: bp elevation not characterized in autonomic section | Journal of Pharmacology and Experimental Therapeutics. Vol. 48, Pg. 410, 1933. |
| dog | LCLo | inhalation | 300mg/m3/30M (300mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 62, 1982. | |
| rat | LD50 | intraperitoneal | 20mg/kg (20mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 17, Pg. 814, 1965. | |
| human | LDLo | oral | 36mg/kg (36mg/kg) | JAMA, Journal of the American Medical Association. Vol. 101, Pg. 1333, 1933. | |
| mouse | LD50 | subcutaneous | 58mg/kg (58mg/kg) | Toxicology and Applied Pharmacology. Vol. 6, Pg. 232, 1964. | |
| mouse | LD50 | oral | 45mg/kg (45mg/kg) | Farmakologiya i Toksikologiya Vol. 28, Pg. 493, 1965. | |
| dog | LDLo | intramuscular | 25mg/kg (25mg/kg) | lungs, thorax, or respiration: respiratory stimulation | Journal of Pharmacology and Experimental Therapeutics. Vol. 48, Pg. 410, 1933. |
| cat | LDLo | subcutaneous | 25mg/kg (25mg/kg) | vascular: bp elevation not characterized in autonomic section | Journal of Pharmacology and Experimental Therapeutics. Vol. 48, Pg. 410, 1933. |
| rat | LD50 | intravenous | 72mg/kg (72mg/kg) | Toxicology and Applied Pharmacology. Vol. 6, Pg. 232, 1964. | |
| dog | LDLo | intravenous | 20mg/kg (20mg/kg) | lungs, thorax, or respiration: respiratory stimulation | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 50, Pg. 20, 1935. |
| dog | LDLo | oral | 30mg/kg (30mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 187, 1933. | |
| dog | LDLo | intramuscular | 25mg/kg (25mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 48, Pg. 410, 1933. | |
| mouse | LD50 | subcutaneous | 50mg/kg (50mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 56, Pg. 23, 1960. | |
| cat | LD50 | oral | 75mg/kg (75mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 62, 1982. | |
| rat | LD50 | oral | 30mg/kg (30mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
| mouse | LD50 | intraperitoneal | 26mg/kg (26mg/kg) | Biochemical Pharmacology. Vol. 18, Pg. 1389, 1969. | |
| .alpha.-Dinitrophenol | 1'alpha-2,4-Dinitrophenol | 1-Hydroxy-2,4-dinitrobenzene |
| 1326-82-5 | 2,4-Dinitrofenol | 2,4-Dinitrofenol [Dutch] |
| 2,4-Dinitrophenol (wetted with 15 % water) | 2,4-Dinitrophenol, PESTANAL(R), analytical standard | 2,4-Dinitrophenol, SAJ special grade, >=98.0% |
| 2,4-Dinitrophenol, moistened with water, >=98.0% | 2,4-Dinitrophenol, technical, moistened with water, >=97.0% (HPLC) | 2,4-Dnp |
| 2,4-dinitro-phenol | 2,4-dinitrophenol | 2,4-dinitrophenol (h2o w/w 18% max) |
| 51-28-5 | 9456-EP2284174A1 | 9456-EP2316829A1 |
| AB00053210_08 | AF-936/31262030 | AI3-01535 |
| AKOS000118988 | AKOS015912556 | ANW-46655 |
| ARONIS010084 | AS-39888 | Aldifen |
| BBL023448 | BIDD:ER0505 | BRD-K21910317-001-02-4 |
| BRD-K21910317-001-06-5 | BRD-K21910317-001-12-3 | BSPBio_003248 |
| C02496 | CAS-51-28-5 | CCG-39730 |
| CCRIS 3102 | CHEBI:42017 | CHEMBL273386 |
| CTK1G9509 | Camello mosquito coils | Caswell No. 392 |
| Chemox PE | Cobra salts (Impregna salts) | D0109 |
| DB04528 | DINITROPHENOL | DNF |
| DSSTox_CID_523 | DSSTox_GSID_20523 | DSSTox_RID_75640 |
| DTXSID0020523 | Dinitrofenolo | Dinitrofenolo [Italian] |
| Dinofan | DivK1c_007034 | EC 200-087-7 |
| EINECS 200-087-7 | EK 102 | EPA Pesticide Chemical Code 037509 |
| Epitope ID:112424 | F0850-6525 | FT-0610210 |
| Fenoxyl | Fenoxyl carbon N | HMS1923K21 |
| HMS2233H07 | HMS3372P06 | HSDB 529 |
| InChI=1/C6H4N2O5/c9-6-2-1-4(7(10)11)3-5(6)8(12)13/h1-3,9 | KBio1_001978 | KBio2_002473 |
| KBio2_005041 | KBio2_007609 | KBio3_002468 |
| KBioGR_001406 | KBioSS_002480 | KS-000041JJ |
| LS-154 | MCULE-6678680789 | MFCD00007115 |
| MLS001066358 | Maroxol-50 | NCGC00091778-01 |
| NCGC00091778-02 | NCGC00091778-03 | NCGC00091778-04 |
| NCGC00091778-05 | NCGC00091778-06 | NCGC00254114-01 |
| NCGC00259013-01 | NE10472 | NSC 1532 |
| NSC-1532 | NSC1532 | Nitro kleenup |
| Nitrophen (VAN) | Nitrophene (VAN) | Osmoplastic-R |
| Osmotox-Plus | Phenol, .alpha.-dinitro- | Phenol, 2,4-dinitro- |
| Phenol, alpha-dinitro- | PubChem11250 | Q13SKS21MN |
| Q209226 | RCRA waste no. P048 | RCRA waste number P048 |
| SC-81242 | SCHEMBL13973810 | SCHEMBL77643 |
| SMR000471854 | SPBio_000765 | SPECTRUM330008 |
| SR-1C5 | STK397797 | Shirakiku brand mosquito coils |
| Solfo Black 2B Supra | Solfo Black B | Solfo Black BB |
| Solfo Black G | Solfo Black SB | SpecPlus_000938 |
| Spectrum2_000673 | Spectrum3_001694 | Spectrum4_000913 |
| Spectrum5_001670 | Spectrum_001934 | Sulphur Black 1 |
| TR-032491 | Tertrosulfur black pb | Tertrosulfur pbr |
| Tertrosulphur Black PB | Tertrosulphur PBR | Tox21_201462 |
| Tox21_300030 | UFBJCMHMOXMLKC-UHFFFAOYSA-N | UNII-Q13SKS21MN |
| W-105909 | WLN: WNR BQ ENW | X 32 |
| ZINC12358776 | alpha-Dinitrophenol |
| DrugBank Name | 2,4-Dinitrophenol |
| DrugBank | DB04528 |
| CAS Number | 1011-73-0, 1326-82-5, 25550-58-7, 51-28-5 |
| PubChem Compound | 1493 |
| KEGG Compound ID | C02496 |
| PubChem.Substance | 46507895 |
| ChEBI | 42017 |
| ChemSpider | 1448 |
| Wikipedia | 2,4-Dinitrophenol |
| HET | DNF |