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Drug

D0320 | Bedaquiline

Molecular Formula C32H31BrN2O2
Molecular Weight 555.5
Structure
State solid
Volume of distribution Vd, central compartment = 164 L
Route of elimination Bedaquiline is primarily elimination in the feces. The urinary excretion of unchanged bedaquiline was < 0.001% of the dose in clinical studies, indicating that renal clearance of unchanged drug is insignificant.
Protein binding >99.9 bound to plasma proteins.
Half life Terminal elimination half-life, bedaquiline and M2 = 5.5 months. This long half-life suggests slow release of bedaquiline and M2 from peripheral tissues.
Absorption Tmax, oral dose = 5 hours; Food increases the oral bioavailability. AUC increases proportionally up to the highest dose studied in healthy volunteers. When 400 mg of bedaquiline is administered once daily for a week, the peak plasma concentration (Cmax) is 5.5 μg/ml and an AUC of 64.75 μgh/ml.

J

J04AK05 Bedaquiline


[J04AK] Other drugs for treatment of tuberculosis


[J04A] DRUGS FOR TREATMENT OF TUBERCULOSIS


[J04] ANTIMYCOBACTERIALS


[J] Antiinfectives for systemic use

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTRON TRANSPORT CHAIN affect 170

Target Dose Time Species Model Method Action Positive criterion Reference
Fo subunits inhibitor 170

Pictogram Signal Statements Precautionary Statement Codes
Danger

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.


H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]


H373 (100%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]


H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]


H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]


 P260, P264, P270, P273, P301+P310, P314, P321, P330, P391, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • (1R)-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2(S)-(1-naphthyl)-1-phenylbutan-2-ol (1R,2S)-1-(6-Bromo-2-methoxy-quinolin-3-yl)-4-methyl-amino-2-naphthalen-1-yl-1-phenyl-butan-2-ol (1R,2S)-1-(6-bromo-2-methoxy-3-quinolyl)-4-(dimethylamino)-2-(1-naphthyl)-1-phenyl-butan-2-ol
    (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(1-naphthyl)-1-phenylbutan-2-ol (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol (alphaS,betaR)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol
    (|AS,|AR)-Bedaquiline 1-(1R)-(6-Bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-(2S)-(naphthalen-1-yl)-1-phenyl-butan-2-ol 1-(6-Bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-ol
    3-Quinolineethanol, 6-bromo-alpha-(2-(dimethylamino)ethyl)-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-, (alphaR,betaS)-rel- 3-Quinolineethanol, 6-bromo-alpha-(2-(dimethylamino)ethyl)-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-, (alphaS,betaR)- 654653-93-7
    78846I289Y 843663-66-1 A12327
    AC-28385 ACN-040787 AIDS 222089
    AIDS-222089 AKOS022186476 AOB87357
    AX8257016 BDBM50063995 Bedaquiline
    Bedaquiline (TMC-207) Bedaquiline (USAN/INN) Bedaquiline [USAN:INN]
    C32H31BrN2O2 CHEBI:72292 CHEMBL376488
    CS-2921 D09872 DB08903
    DTXSID80903989 HSDB 8217 HY-14881
    J-500265 KS-0000002K MMV689758
    NCGC00348215-01 NCGC00348215-04 Q1257318
    R 207910 R-207910 R207910
    R207910 R403323 SCHEMBL295482
    TMC 207 TMC-207 TMC207
    TMC207 Tube401 UNII-78846I289Y
    ZINC4655029 bedaquilina bedaquilinum
    bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-ol

    DrugBank Name Bedaquiline
    DrugBank DB08903
    CAS Number 654653-81-3, 654653-93-7, 843663-66-1
    PubChem Compound 5388906
    KEGG Compound ID C14122
    KEGG Drug D09872
    PubChem.Substance 175427143
    ChEBI 72292
    ChemSpider 4534966
    BindingDB 50063995.0
    Wikipedia Bedaquiline
    HET BQ1