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Drug

D0395 | Rhein

Molecular Formula C15H8O6
Molecular Weight 284.22
Structure
State solid
Clearance Total CL is 1.5 L/h and renal CL is 0.1 L/h [A19300].
Volume of distribution 15-60L [A19300].
Route of elimination 37% is excreted in urine and 53% in feces as estimated in rats [A19250].
Protein binding 99% bound to plasma proteins [A19300].
Half life 4-10h [A19300].
Absorption Tmax of 1.6-2.6 hours [A19300].

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 6.06±5.91 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 8.91 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 11.58±4.85 rat hepatocytes MMP assay decrease IC50 163
ELECTRON TRANSPORT CHAIN 30 μM bovine mitochondria NADH:O2 decrease IC50 104

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase 30 μM bovine mitochondria NADH:O2 inhibitor IC50 104

Pictogram Signal Statements Precautionary Statement Codes
Warning

Aggregated GHS information provided by 201 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]


H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (99.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 1,8-DIHYDROXY-3-CARBOXYL ANTHRAQUINONE 1,8-Dihydroxy-3-carboxyanthraquinone 1,8-Dihydroxyanthraquinone-3-carboxylic acid
    1,8-dihydroxy-3-carboxyl-9,10-anthraquinone 2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- 2-Anthracenecarboxylic acid,10-dihydro-4,5-dihydroxy-9,10-dioxo-
    2-Anthraquinonecarboxylic acid, 4,5-dihydroxy- 2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- 2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- (8CI)
    2-Anthroic acid,10-dihydro-4,5-dihydroxy-9,10-dioxo- 4, 5-Dihydroxyanthraquinone-2-carboxylic acid 4,5-DiOH-anthraquinone-2-COOH
    4,5-Dihydroxy-2-anthraquinonecarboxylic acid 4,5-Dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenecarboxylic acid # 4,5-Dihydroxyanthraquinone-2-carboxylic acid
    4,5-bis(oxidanyl)-9,10-bis(oxidanylidene)anthracene-2-carboxylic acid 4,5-dihydroxy-9,10-diketo-anthracene-2-carboxylic acid 4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid
    4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid 4,5-dihydroxy-9,10-dioxo-anthracene-2-carboxylic acid 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid
    4-10-00-04088 (Beilstein Handbook Reference) 478-43-3 478-43-3,202053-60-9(monosodiumsalt)
    4ie7 78R433 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracene carboxylic acid
    9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, 9CI 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroic acid
    9,10-Dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid AB0010467 AC-7978
    ACMC-209kan ACN-035339 ACT03257
    ACon1_000217 AK-88490 AKOS005259272
    AM807834 ANW-30573 AS-11635
    BBL009695 BCP28202 BDBM32021
    BRD-K27335680-001-01-9 BRN 2222155 C10401
    C15H8O6 CAS-478-43-3 CCRIS 5129
    CHEBI:8825 CHEMBL418068 CR-006
    CR0016 CS-5239 CTK4J0379
    Cassic acid Chrysazin-3-carboxylic acid D3986
    DB-014981 DB13174 DSSTox_CID_6000
    DSSTox_GSID_26000 DSSTox_RID_77984 DTXSID4026000
    EINECS 207-521-4 FCDLCPWAQCPTKC-UHFFFAOYSA-N FT-0645050
    HY-N0105 KS-00000NFX LMPK13040015
    LS-129 MCULE-1248137705 MEGxp0_001866
    MFCD00009618 MFCD00009618 (95%) MLS000069639
    MLS006011744 Monorhein Monorhein, NSC 38629, Rheic acid, Rheinic acid, Rhubarb yellow, 478-43-3
    N1810 NCGC00018199-01 NCGC00018199-02
    NCGC00018199-03 NCGC00018199-04 NCGC00018199-05
    NCGC00018199-06 NCGC00018199-07 NCGC00023342-03
    NCGC00023342-04 NCGC00258650-01 NSC 38629
    NSC-38629 NSC38629 Q-100512
    Q720356 RHN RTR-031414
    Rheic acid Rhein Rhein
    Rhein (1,8-dihydroxy-3-carboxyl anthraquinone) Rhein - Monorhein Rhein(Monorhein)
    Rhein, analytical standard Rhein, technical grade Rhein,(S)
    Rheinic acid Rhubarb Yellow Rhubarb Yellow
    SBB001152 SC-25777 SCHEMBL25253
    SMR000058210 ST057726 ST2405253
    STL141046 SY051290 TR-031414
    Tox21_201098 UNII-YM64C2P6UX US9238626, Rhein
    X-4365 YM64C2P6UX ZINC4098704
    cid_10168 dipropionyl rhein regid855879
    s2400

    DrugBank Name Rhein
    DrugBank DB13174
    CAS Number 478-43-3, 50-62-4
    PubChem Compound 10168
    KEGG Compound ID C10401
    PubChem.Substance 347829278
    ChEBI 8825
    ChemSpider 9762
    BindingDB 32021.0
    Wikipedia Rhein_(molecule)
    HET RHN