Search References Drug Actions/Targets About Access data Feedback
Sign In
mitontu@gmail.com
2021 MitoTox | (CC BY-NC 4.0)
Compound

D0472 | zoniporide

Molecular Formula C17H16N6O
Molecular Weight 320.3
Structure
Description inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1)

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTRON TRANSPORT CHAIN decrease 50
GLUCOSE GALACTOSE IC50 RATIO 300.0 ± 0, 300.0 ± 0, 1, 300.0 ± 0, 251.0 ± 54.7, 1.2 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Negative glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50
GLUCOSE GALACTOSE IC50 RATIO 300.00 ± 0, 22.1 ± 14.3, 13.6, 300.0 ± 0, 21.6 ± 5.1, 13.9 24hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase inhibitor 50


  • 8841R2UJPG CP-597,396 CP-597396
    DTXSID0057883 N-Carbamimidoyl-5-cyclopropyl-1-(quinolin-5-yl)-1H-pyrazole-4-carboxamide; Q27269884
    UNII-8841R2UJPG Zoniporide [INN:BAN]

    PubChem Compound 135564783