Drug
D0489 | tenidap
M
M01AX23 Tenidap
[M01AX] Other antiinflammatory and antirheumatic agents, non-steroids
[M01A] ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
[M01] ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
[M] Musculoskeletal system
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| UNCOUPLING | rat | isolated liver mitochondria | measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay | increase | 53 | |||
| MEMBRANE POTENTIAL | 12.53±1.19 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 15.85 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 21.05±7.88 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| ELECTRON TRANSPORT CHAIN | rat | isolated liver mitochondria | measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay | decrease | 53 | |||
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD | oral | > 300mg/kg (300mg/kg) | Journal of Medicinal Chemistry. Vol. 35, Pg. 2863, 1992. | |
| (3Z)-5-CHLORO-3-[HYDROXY(2-THIENYL)METHYLENE]-2-OXO-2,3-DIHYDRO-1H-INDOLE-1-CARBOXAMIDE | (3Z)-5-chloro-3-[hydroxy(2-thienyl)methylene]-2-oxo-indoline-1-carboxamide | (3Z)-5-chloro-3-[hydroxy(2-thienyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-1-carboxamide |
| (3Z)-5-chloro-3-[hydroxy(thiophen-2-yl)methylidene]-2-oxoindole-1-carboxamide | (E)-5-chloro-3-(hydroxy(thiophen-2-yl)methylene)-2-oxoindoline-1-carboxamide | (E)-Tenidap |
| (Z)-5-Chloro-3-(alpha-hydroxy-2-thenylidene)-2-oxo-1-indolinecarboxamide | (Z)-5-chloro-3-(hydroxy(thiophen-2-yl)methylene)-2-oxoindoline-1-carboxamide | (z)-5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1h-indole-1-carboxamide |
| 120210-48-2 | 1H-Indole-1-carboxamide, 5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-, (Z)- | 2-Hydroxy-3-(2-thienylcarbonyl)-5-chloro-1H-indole-1-carboxamide |
| 5-Chloro-2,3-dihydro-3-[hydroxy(2-thienyl)methylene]-2-oxo-1H-indole-1-carboxamide | 5-Chloro-2-oxo-3-(thiophene-2-carbonyl)-2,3-dihydro-indole-1-carboxylic acid amide | 5-Chloro-2-oxo-3-(thiophene-2-carbonyl)-2,3-dihydro-indole-1-carboxylic acid amide(tenidap) |
| 5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide | 5-chloro-2,3-dihydro-3-[hydroxy-(2-thienyl)methylene]-2-oxo-1H-indole-1-carboxamide | 5-chloro-2-hydroxy-3-(thiophene-2-carbonyl)-1H-indole-1-carboxamide |
| 5-chloro-2-oxo-3-(thiophene-2-carbonyl)-3H-indole-1-carboxamide | 9K7CJ74ONH | AKOS000280742 |
| AKOS030254774 | API0013661 | B7115 |
| BDBM50331888 | C14H9ClN2O3S | CAS-120210-48-2 |
| CHEBI:35847 | CHEMBL1097558 | CHEMBL1908355 |
| CP 66,248 | CP 66248-2 | CP-66,248 |
| CP-66,248-2 | CS-0024729 | CTK8E8302 |
| D06072 | DB-041542 | DB13481 |
| DSSTox_CID_26104 | DSSTox_GSID_46104 | DSSTox_RID_81342 |
| DTXSID9046104 | EC-000.2272 | FT-0631099 |
| GTPL2395 | HMS3269D11 | HMS3413H21 |
| HMS3677H21 | HY-105028 | IL-6+Tenidap |
| Interleukin-6 & [Z]-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide; | J-004277 | LS-172439 |
| LXIKEPCNDFVJKC-UHFFFAOYSA-N | NCGC00160352-01 | NCGC00167784-01 |
| NCGC00263542-01 | Q7699849 | RT-015905 |
| SCHEMBL1651222 | SCHEMBL24922 | SCHEMBL3751878 |
| SR-01000883975 | SR-01000883975-1 | TENIDAP |
| Tenidap (USAN/INN) | Tenidap [USAN:BAN:INN] | Tenidap [USAN:INN:BAN] |
| Tenidap sodium salt | Tenidapum | Tenidapum [INN-Latin] |
| Tox21_111757 | Tox21_111757_1 | UNII-9K7CJ74ONH |
| ZINC100001953 | ZINC104069448 | [Z]-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide |