MITOTOX

Drug

D0524 | atpenin a5

Properties

Molecular Formula	C15H21Cl2NO5
Molecular Weight	366.2
Structure
State	solid
Description	antifungal antibiotic; highly specific ubiquinone-binding site inhibitor of succinate dehydrogenase; complex II inhibitor

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
ELECTRON TRANSPORT CHAIN						affect		71
ELECTRON TRANSPORT CHAIN						affect		72
ELECTRON TRANSPORT CHAIN			bovine	heart mitochondria		affect		192
GLUCOSE GALACTOSE IC50 RATIO	1.2			LUHMES (Lund human mesencephalic) cells	Glc–Gal–NeuriTox assay	Negative	EC25(NA) [Glc/Gal]	326

Targets

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
Succinate dehydrogenase	1.2			LUHMES (Lund human mesencephalic) cells	Glc–Gal–NeuriTox assay	Negative	EC25(NA) [Glc/Gal]	326
Quinone pocket						inhibitor		71
Quinone pocket						inhibitor		72
Quinone pocket			bovine	heart mitochondria		inhibitor		192

Indications Source: SIDER

Synonyms Source: PubChem

119509-24-9	3-[(2S,4S,5R)-5,6-DICHLORO-2,4-DIMETHYL-1-OXOHEXYL]-4-HYDROXY-5,6-DIMETHOXY-2(1H)-PYRIDINONE	3-[(2S,4S,5R)-5,6-dichloro-2,4-dimethylhexanoyl]-4-hydroxy-5,6-dimethoxypyridin-2(1H)-one;
AA5	AT5	ATPENIN A5
Atpenin A5	CHEMBL1081615	DB04631
DTXSID60152478	J-004142	LS-22198
Q27095367	SCHEMBL1506735	SCHEMBL20472249
ZINC14262625

External IDs

DrugBank Name	atpenin a5
DrugBank	DB04631
CAS Number	119509-24-9
PubChem Compound	54676868

References