MITOTOX

Compound

D0550 | NQNO

Properties

Molecular Formula	C18H25NO2
Molecular Weight	287.4
Structure
Description	bind to mitochondrial Cytochrome bc1 (Pf class)

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
ELECTRON TRANSPORT CHAIN			bovine	isolated heart mitochondria cytochrome bc1 complex		affect		166
ELECTRON TRANSPORT CHAIN			bovine	isolated heart mitochondria cytochrome bc1 complex		affect		166

Targets

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
Qo site (Qp site or ubiquinol oxidation site)			bovine	isolated heart mitochondria cytochrome bc1 complex		inhibitor		166
Qi site (Qn site or quinone reduction site)			bovine	isolated heart mitochondria cytochrome bc1 complex		inhibitor		166

Indications Source: SIDER

Synonyms Source: PubChem

1-hydroxy-2-nonylquinolin-4(1h)-one	1nu1	2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
2-Nonyl-4-quinolinol 1-oxide	2-n-nonyl-4-hydroxyquinoline-N-oxide	2-nonylquinolin-4-ol 1-oxide
316-66-5	4-Quinolinol, 2-nonyl-, 1-oxide	4-Quinolinol, 2-nonyl-,1-oxide
CHEMBL1235570	CTK4G7551	DB08453
DTXSID00953562	NQ-N-Oxide	NQNO
Nonyl-4-hydroxyquinoline-N-oxide	Q27097658;	SCHEMBL21065470
SCHEMBL4946320	ZINC000100036761

External IDs

CAS Number	316-66-5, 4663-86-9
PubChem Compound	130804

References