Drug

D0844 | chloroxine

Molecular Formula C9H5Cl2NO
Molecular Weight 214.04
Structure
State solid

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 10.59±1.22 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 9.75 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL rat hepatocytes MMP assay Negative IC50 163
GLUCOSE GALACTOSE IC50 RATIO 300.0 ± 0, 300.0 ± 0, 1, 300.0 ± 0, 300.0 ± 0, 1 4hr H9c2 cells high-glucose–galactose cell viability assay with JC-1 mitochondrial membrane potential and ATP-depletion assays (CellTiter-Glo reagent ). Negative glucose/galactose IC50 ratio (JC-1 IC50 in glucose, JC-1 IC50 in galactose, JC-1 glu/gla, ATP IC50 in glucose, ATP IC50 in galactose, ATP glu/gla ) 50

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 47 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.


H302 (89.36%): Harmful if swallowed [Warning Acute toxicity, oral]


H315 (97.87%): Causes skin irritation [Warning Skin corrosion/irritation]


H318 (87.23%): Causes serious eye damage [Danger Serious eye damage/eye irritation]


H319 (10.64%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]


H335 (95.74%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure


Respiratory tract irritation]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)

Organism Test type Route Dose (normalized dose) Effect Source
rabbit LD50 oral 160mg/kg (160mg/kg) "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 33, 1969.
rat LD50 oral 660mg/kg (660mg/kg) "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 33, 1969.
dog LD50 oral 2250mg/kg (2250mg/kg) "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 33, 1969.


  • 2I8BD50I8B 5,7-Dichlor-8-hydroxychinolin 5,7-Dichlor-8-hydroxychinolin [German]
    5,7-Dichloro-8-hydroquinoline 5,7-Dichloro-8-hydroxy-quinoline 5,7-Dichloro-8-hydroxyquinoline
    5,7-Dichloro-8-hydroxyquinoline, 99% 5,7-Dichloro-8-oxine 5,7-Dichloro-8-oxyquinoline
    5,7-Dichloro-8-quinolinol 5,7-Dichloro-8-quinolinol, 99% 5,7-Dichlorooxine
    5,7-Dichloroquinolin-8-ol 5,7-Dichloroxine 5-21-03-00286 (Beilstein Handbook Reference)
    773-76-2 8-QUINOLINOL, 5,7-DICHLORO- 8-Quinolinol,7-dichloro-
    A9795 AB00052323-08 AB00052323_09
    AB00052323_10 AB2000325 AC-4820
    ACMC-209p9h AK-89722 AKOS000271338
    ANW-37011 AS-229 BDBM32147
    BIDD:GT0763 BRD-K17075857-001-06-9 BRN 0153606
    BSPBio_002711 C9H5Cl2NO CAS-773-76-2
    CCG-40039 CCRIS 5751 CHEBI:59477
    CHEMBL1200596 CHQ CPD000312779
    CS-2324 CTK3J5578 Capitrol
    Capitrol (TN) Capitrol Cream Shampoo Capitrol Cream Shampoo (Salt/Mix)
    Chlofucid Chlorohydroxyquinoline Chloroxine (USAN)
    Chloroxine [USAN] Chloroxyquinoline Chlorquinol
    Clofuzid D03472 D0412
    DB01243 DSSTox_CID_2801 DSSTox_GSID_22801
    DSSTox_RID_76734 DTXSID5022801 Dichlorohydroxyquinoline
    Dichloroquinolinol Dichloroxin Dikhloroskin
    DivK1c_000578 EINECS 212-258-3 Endiaron
    F0918-0943 FT-0623709 HMS1923K05
    HMS2092N04 HMS2609A16 HMS3259E17
    HMS3655G16 HMS3712O06 HMS501M20
    HY-B0295 IDI1_000578 KBio1_000578
    KBio2_001914 KBio2_004482 KBio2_007050
    KBio3_002211 KBioGR_001068 KBioSS_001914
    KS-00000FNW KSC495K7R LS-142531
    MCULE-3987057340 MLS000681736 NC00505
    NCGC00095264-01 NCGC00095264-02 NCGC00095264-03
    NCGC00095264-04 NCGC00095264-05 NINDS_000578
    NSC 3904 NSC-3904 NSC-758398
    NSC3904 NSC758398 Oprea1_486275
    Pharmakon1600-01503202 PubChem21919 Q12029435
    Quesyl Quinolor Quixalin
    REGID_for_CID_2722 RTR-024734 SAM002554895
    SBB039926 SBI-0051782.P002 SC-75357
    SCHEMBL3350 SMR000312779 SPBio_000813
    SPECTRUM1503202 SQ 16401 SR-01000747474
    SR-01000747474-2 SR-01000747474-3 ST24029249
    ST50160577 STK075368 SW198618-2
    SY016017 Spectrum2_000687 Spectrum3_001156
    Spectrum4_000744 Spectrum5_001444 Spectrum_001434
    TG2-36-1 TR-024734 TRA0059012
    Tox21_111494 Tox21_111494_1 UNII-2I8BD50I8B
    UNII-Z7Z4BX535U component WDFKMLRRRCGAKS-UHFFFAOYSA-N; UPCMLD0ENAT5752182:001 W-104320
    WDFKMLRRRCGAKS-UHFFFAOYSA-N ZINC1131 chloroxine
    cid_2722 component of Capitrol Cream Shampoo dichloroquine
    s1839

    DrugBank DB01243
    CAS Number 63024-18-0, 72-80-0, 773-76-2, 95864-17-8
    PubChem Compound 2722
    KEGG Drug D03472
    ChEBI 59477