D0862 | cyhalothrin
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 33.62±5.79 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | human | HepG2 | MMP assay | Negative | IC50 | 163 | ||
| MEMBRANE POTENTIAL | 33.80±9.96 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| ELECTRON TRANSPORT CHAIN | 0.6 μM | NADH–DQ | decrease | IC50 | 110 | |||
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| NADH:ubiquinone reductase | 0.6 μM | NADH–DQ | inhibitor | IC50 | 110 | |||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H312: Harmful in contact with skin [Warning Acute toxicity, dermal] H330: Fatal if inhaled [Danger Acute toxicity, inhalation] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P260, P264, P270, P271, P273, P280, P284, P301+P310, P302+P352, P304+P340, P310, P312, P320, P321, P322, P330, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Danger |
Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301 (97.5%): Toxic if swallowed [Danger Acute toxicity, oral] H315 (95%): Causes skin irritation [Warning Skin corrosion/irritation] H317 (95%): May cause an allergic skin reaction [Warning Sensitization, Skin] H319 (97.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H330 (97.5%): Fatal if inhaled [Danger Acute toxicity, inhalation] H400 (97.5%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (97.5%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P310, P302+P352, P304+P340, P305+P351+P338, P310, P320, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Danger |
Aggregated GHS information provided by 251 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] H311 (77.29%): Toxic in contact with skin [Danger Acute toxicity, dermal] H312 (22.71%): Harmful in contact with skin [Warning Acute toxicity, dermal] H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation] H400 (84.86%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P264, P270, P271, P273, P280, P284, P301+P310, P302+P352, P304+P340, P310, P312, P320, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
 |
Danger |
Aggregated GHS information provided by 227 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] H311 (15.86%): Toxic in contact with skin [Danger Acute toxicity, dermal] H312 (84.14%): Harmful in contact with skin [Warning Acute toxicity, dermal] H319 (15.42%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation] H370 (15.42%): Causes damage to organs [Danger Specific target organ toxicity, single exposure] H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P264, P270, P271, P273, P280, P284, P301+P310, P302+P352, P304+P340, P305+P351+P338, P307+P311, P310, P312, P320, P321, P322, P330, P337+P313, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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|
Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H312: Harmful in contact with skin [Warning Acute toxicity, dermal] H330: Fatal if inhaled [Danger Acute toxicity, inhalation] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P260, P264, P270, P271, P273, P280, P284, P301+P310, P302+P352, P304+P340, P310, P312, P320, P321, P322, P330, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
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Danger |
H301: Toxic if swallowed [Danger Acute toxicity, oral] H311: Toxic in contact with skin [Danger Acute toxicity, dermal] H320: Causes eye irritation [Warning Serious eye damage/eye irritation] H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure Respiratory tract irritation] H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P260, P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P307+P311, P312, P314, P321, P322, P330, P337+P313, P361, P363, P391, P403+P233, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | intravenous | 1951ug/kg (1.951mg/kg) | Pesticide Biochemistry and Physiology. Vol. 30, Pg. 79, 1988. | |
| rat | LD50 | oral | 56mg/kg (56mg/kg) | Pesticide Manual. Vol. 9, Pg. 203, 1991. | |
| rat | LD50 | skin | 632mg/kg (632mg/kg) | Pesticide Manual. Vol. 9, Pg. 203, 1991. | |
| mammal (species unspecified) | LC50 | inhalation | 60mg/m3/4H (60mg/m3) | Pesticide Manual. Vol. 9, Pg. 203, 1991. | |
| duck | LD50 | oral | > 3950mg/kg (3950mg/kg) | Farm Chemicals Handbook. Vol. -, Pg. C175, 1991. | |
| (1alpha,3alpha(Z))-(+-)-Cyano-(3-phenoxyphenyl)methyl 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate | (RS)-alpha-Cyano-3-phenoxybenzyl (Z)-(1RS,3RS)-(2-chloro-3,3,3- trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylate | (RS)-alpha-Cyano-3-phenoxybenzyl (Z)-(1RS,3RS)-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylate |
| (Z)-cyano(3-phenoxyphenyl)methyl 3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate | .alpha-cyano-3-phenoxybenzyl 3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2- dimethyl cyclopropanecarboxylate | 085C858 |
| 3-(2-Chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcycloproanecarboxylic acid cyano(3-phenoxyphenyl)methyl ester | 3-(2-Chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid cyan(3-phenoxyphenyl)methyl ester | 3-(2-Chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid cyano(3-phenoxyphenyl)methyl ester |
| 3-[(Z)-2-Chloro-3,3,3-trifluoro-1-propenyl]-2,2-dimethylcyclopropanecarboxylic acid alpha-cyano-3-phenoxybenzyl ester | 527-EP2274983A1 | 527-EP2275422A1 |
| 527-EP2280009A1 | 527-EP2292608A1 | 527-EP2308857A1 |
| 527-EP2308858A1 | 527-EP2311816A1 | 527-EP2311817A1 |
| 527-EP2314583A1 | 538-EP2308857A1 | 68085-85-8 |
| 91465-08-6 | AS-15902 | C10983 |
| CHEBI:4035 | CHEMBL2105498 | CYHALOTHRIN |
| Coopertix [veterinary] (TN) | Cyano(3-phenoxyphenyl)methyl 3-(2-chloro-3,3,3-trifluoro-1-propen-1-yl)-2,2-dimethylcyclopropanecarboxylate; | Cyclopropanecarboxylic acid, 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl-, cyano(3-phenoxyphenyl)methyl ester |
| Cyhalothrin (BAN) | Cyhalothrin [BAN] | Cyhalothrin [BSI:ISO] |
| Cyhalothrin solution, 100 mug/mL in acetonitrile, PESTANAL(R), analytical standard | Cyhalothrin, analytical standard | Cyhalothrine |
| Cyhalothrine [ISO-French] | D07762 | DTXSID6023997 |
| EINECS 268-450-2 | EPA Pesticide Chemical Code 128867 | Grenade |
| HSDB 6791 | ICI 146814 | Ici-pp 563 |
| NCGC00248527-01 | PP 563 | PP-563 |
| Q421593 | SB18909 | SCHEMBL23923 |
| Saber | Scimitar | W-111325 |
| ZXQYGBMAQZUVMI-UNOMPAQXSA-N | [cyano-(3-phenoxyphenyl)methyl] 3-[(Z)-2-chloro-3,3,3-trifluoro-prop-1-enyl]-2,2-dimethyl-cyclopropanecarboxylate | alpha-Cyano-3-phenoxybenzyl 3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate |
| alpha-Cyhalothrin | cyano(3-phenoxyphenyl)methyl 3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylate | lambda-Cyhalothrin |