Drug

D1040 | penfluridol

Molecular Formula C28H27ClF5NO
Molecular Weight 524
Structure
Description a highly potent, first generation diphenylbutylpiperidine antipsychotic

N

N05AG03 Penfluridol


[N05AG] Diphenylbutylpiperidine derivatives


[N05A] ANTIPSYCHOTICS


[N05] PSYCHOLEPTICS


[N] Nervous system


Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 33.49±0.00 human qHTS-HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 27.48 human HepG2 MMP assay decrease IC50 163
MEMBRANE POTENTIAL 23.24±6.57 rat hepatocytes MMP assay decrease IC50 163
ELONGATION mouse neuron Mitochondrial morphology and neurite area measurements induce 269

Pictogram Signal Statements Precautionary Statement Codes
Danger

Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory.


H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


P264, P270, P301+P310, P321, P330, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 1-(4,4-Bis(p-fluorophenyl)butyl)-4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-4-piperidinol 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol 1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol
    1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol 1-[4,4-Bis(p-fluorophenyl)butyl]-4-(4-chloro-.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)-4-piperidinol 1-[4,4-Bis(p-flurophenyl)butyl]-4-(4-chloro-.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)-4-piperidinol
    1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidin-4-ol 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloranyl-3-(trifluoromethyl)phenyl]piperidin-4-ol 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-piperidin-4-ol
    1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-ol 25TLU22Q8H 26864-56-2
    4-Piperidinol, 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)- 4-Piperidinol, 1-(4,4-bis(p-fluorophenyl)butyl)-4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)- 4-Piperidinol, 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-
    4-Piperidinol, 4-(4-chloro-.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)-1-(4,4-bis(p-fluorophenyl)butyl)- 4-Piperidinol, 4-(4-chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-1-(4,4-bis(p-fluorophenyl)butyl)- 4-Piperidinol,1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-
    4CA-0984 5-21-02-00409 (Beilstein Handbook Reference) 864P562
    A818637 AB0011815 AB01566919_01
    AC-15413 ACT03196 AK-73104
    AKOS005065828 AOB5341 API0003774
    AX8009267 BCP03695 BCP0726000159
    BCP9000014 BDBM50026066 BR-73104
    BRD-K15409150-001-01-7 BRN 1558826 C28H27ClF5NO
    CAS-26864-56-2 CHEBI:92278 CHEMBL47050
    CS-4633 CTK8E9221 D02630
    DB-017683 DB13791 DSSTox_CID_28947
    DSSTox_GSID_49021 DSSTox_RID_83212 DTXSID5049021
    EINECS 248-074-5 FT-0645031 HMS3264L13
    HMS3652G22 HY-B1077 KS-00000NV3
    KS-5104 L001145 LS-116932
    MCN-JR-16341 MDLAAYDRRZXJIF-UHFFFAOYSA-N MFCD00866714
    MLS004774011 McN-JR-16,341 Micefal
    NCGC00165865-01 NCGC00165865-02 NCGC00165865-03
    NSC-759179 NSC759179 P2076
    PDSP1_000470 PDSP2_000468 PENFLURIDOL
    PENFLURIDOL1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidin-4-ol; Penfluridol (USAN/INN) Penfluridol [USAN:BAN:INN]
    Penfluridol [USAN:INN:BAN] Penfluridol, >=97% (HPLC), powder Penfluridolum
    Penfluridolum [INN-Latin] Pharmakon1600-01505691 PubChem15873
    Q2149707 R 16,341 R 16341
    R-16341 R16341 S-3876
    S4151 SBI-0206898.P001 SC-13777
    SCHEMBL93939 SMR003500704 SR-05000001779
    SR-05000001779-1 ST2408559 SW219540-1
    Semap Semap (TN) TLP-607
    TR-012101 Tox21_113546 Tox21_113546_1
    UNII-25TLU22Q8H VZ21058 W-107147
    ZINC4217252

    DrugBank DB13791
    CAS Number 26864-56-2, 4985-42-6
    PubChem Compound 33630
    KEGG Drug D02630