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Drug

D1380 | pitavastatin

Molecular Formula C25H24FNO4
Molecular Weight 421.5
Structure
State solid
Clearance CL/F (apparent clearance), 4 mg, healthy male Korean subjects = 23.6 L/h
Volume of distribution 148 L
Route of elimination 79% in feces and 15% excreted in urine.
Protein binding >99% protein bound in human plasma, mainly to albumin and alpha 1-acid glycoprotein.
Half life Plasma elimination half-lfie = 12 hours
Absorption Bioavailability = 51%; Time to peak, plasma = 1 hour; Pitavastatin was absorbed in the small intestine but very little in the colon. Cmax decreases by 43% if pitavastatin is taken with a fatty meal but there are no significant changes to AUC or baseline LDL levels compared to fasting state. The Cmax and AUC of pitavastatin did not differ following evening or morning drug administration.
Trade names Livalo
Description statin; inhibiting HMG-CoA reductase

C

C10AA08 Pitavastatin


[C10AA] HMG CoA reductase inhibitors


[C10A] LIPID MODIFYING AGENTS, PLAIN


[C10] LIPID MODIFYING AGENTS


[C] Cardiovascular system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTRON TRANSPORT CHAIN 100uM C2C12 myoblasts measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds decrease 180

Target Dose Time Species Model Method Action Positive criterion Reference
Quinol--cytochrome-c reductase 100uM C2C12 myoblasts measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds inhibitor 180

Pictogram Signal Statements Precautionary Statement Codes
Warning

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.


H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]


H362 (100%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]


 P201, P202, P260, P263, P264, P270, P281, P308+P313, P405, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • ( )-(3R,5S,6E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-heptenoic acid (3R,5S)-3,5-Dihydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-6-heptenoic acid (3R,5S,6E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid
    (3R,5S,6E)-7-(2-Cyclopropyl-4-(p-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-heptenoic acid (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy hept-6-enoic acid (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid
    (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (3r,5s,6e)-7-[2-cyclopropyl-4-(p-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoic acid (E)-(3R,5S)-7-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid
    (E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid (e)-(3r,5s)-7-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3,5-dihydroxy-hept-6enoic acid 121659-03-8
    147511-69-1 3972AH 6-Heptenoic acid, 7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)-3,5-dihydroxy-, (3R,5S,6E)-
    6-Heptenoic acid, 7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)-3,5-dihydroxy-, (S-(R*,S*-(E)))- AKOS005145916 AM84440
    API0003879 BDBM86707 BRD-K75958547-001-01-2
    C25H24FNO4 CAS_147511-69-1 CHEBI:32020
    CHEMBL1201753 CS-2110 DB08860
    DTXSID1048384 E-(3R,5S)-7-[2-Cyclopropyl-4-(4fluoro-phenyl)quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid GTPL3035
    HSDB 8367 HY-B0144A Itavastatin
    Itavastatin|||Nisvastatin|||NK-104|||P-872441|||(E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid Itavastin LS-74594
    Livalo M5681Q5F9P MLS006010096
    NK 104 NK-104 P 872441
    P-872441 Pitavastatin Pitavastatin [INN]
    Pitavastatin calcium Pitavastatin calcium (JAN) Q412677
    SCHEMBL3369 SCHEMBL464781 SMR003965244
    UNII-M5681Q5F9P ZINC1534965 Zypitamag
    pitavastatia pitavastatine pitavastatinum

    DrugBank DB08860
    CAS Number 121659-03-8, 147511-69-1, 147526-32-7
    PubChem Compound 5282452