F020605 | Phospholipid metabolism
| Compound | Dose | Time | Species | Model | Method | Action | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Troglitazone | 10 µM | ZDF fa/fa rat vs ZDF lean rat | isolated mitochondria | Oxidation of mitochondrial phospholipids was measured by HPLC analysis. Peak area ratio (235/206 nm) shows relative peroxidative phospholipid content. Peak areas at 206 nm and 235 nm analyze non-peroxidative and peroxidative phospholipid. | peroxidation | Positive | significantly different from ZDF lean rats (p < 0.05) | 225 | |