Compound | Dose | Time | Species | Model | Method | Action | Result | Positive criterion | Reference |
---|---|---|---|---|---|---|---|---|---|
Perhexiline | decrease | Positive | 16 | ||||||
Perhexiline | decrease | Positive | 16 | ||||||
Diazoxide | EC50= 40mmol/L, saturation by 100mmol/L | Primary Culture of Neonatal Rat Cardiac Ventricular Myocytes | flow cytometry and quantitative image analysis of cells stained with fluorescent DC indicators. | affect | Positive | 188 | |||
Pinacidil | affect | Positive | 188 | ||||||
5-Hydroxydecanoate | 500mmol/L | Primary Culture of Neonatal Rat Cardiac Ventricular Myocytes | flow cytometry and quantitative image analysis of cells stained with fluorescent DC indicators. | affect | Positive | 188 | |||
Glibenclamide | affect | Positive | 188 | ||||||
Glibenclamide | K1/2 values 1-6 microM | heart and liver mitochondria from rat | affect | Positive | 190 | ||||