F031001 | Mitochondrial respiratory chain complex assembly

Organization of mitochondria >> Protein-containing complex assembly >> mitochondrial respiratory chain complex assembly

Compound Dose Time Species Model Method Action Result Positive criterion Reference
doxycycline 15 µg/ml 6 days 143B osteosarcoma cells BN PAGE analysis, In-gel complex I activity and western blotting inhibitor Positive 285
Chloramphenicol 50 μg/ml 5 days 143B osteosarcoma cells Blue Native Gel inhibitor Positive 286
Chloramphenicol 50µg/mL 4 days complex I de novo assembly analysed by BN-PAGE inhibitor Positive 287
Saquinavir decrease Positive 307