Compound | Dose | Time | Species | Model | Method | Action | Result | Positive criterion | Reference |
---|---|---|---|---|---|---|---|---|---|
8-OH-DPAT | 10nM | 2h | rat | Hippocampal Neurons | time-lapse imaging experiments | increase | Positive | 215 | |
1,3-Dihydro-1-(1-(4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one | 5 μM | 30min | rat | Hippocampal Neurons | time-lapse imaging experiments | decrease | Positive | 215 | |
alpha-4-Dibromoacetophenone | 0.05 μM | 2h | rat | Hippocampal Neurons | time-lapse imaging experiments | increase | Positive | paired t-test; p < 0.02 | 215 |
bromocriptine | 5 µM | 2h | rat | Hippocampal Neurons | time-lapse imaging experiments | decrease | Positive | 216 | |
SKF38393 | 33 µM | 2h | rat | Hippocampal Neurons | time-lapse imaging experiments | increase | Positive | paired t-test; p < 0.02 | 216 |
Haloperidol | 10 µM | 2h | rat | Hippocampal Neurons | time-lapse imaging experiments | increase | Positive | 216 | |
SCH23390 | 55 µM | 2h | rat | Hippocampal Neurons | time-lapse imaging experiments | decrease | Positive | 216 | |
CCCP | 1mM | Neurons derived from the dorsal root ganglia of embryonic-day-14 (E14) chicken embryos | time-lapse microscopy, Kymograph | decrease | Positive | 219 | |||
mannitol | 200 mM | Neurons derived from the dorsal root ganglia of embryonic-day-14 (E14) chicken embryos | time-lapse microscopy, Kymograph | decrease | Positive | 219 | |||
serotonin | 29nM | 2h | rat | Hippocampal Neurons | time-lapse imaging experiments | increase | Positive | 215 | |
dopamine | 30 nM | 2h | rat | Hippocampal Neurons | time-lapse imaging experiments | decrease | Positive | 216 | |
WAY-100635 | 10nM | 2h | rat | Hippocampal Neurons | time-lapse imaging experiments | decrease | Positive | 215 | |
Fluoxetine | 3 μM | rat | Hippocampal Neurons | time-lapse imaging experiments | increase | Positive | 215 | ||