T027 Source: Uniprot
enzyme familyLong-chain-fatty-acid--CoA ligase
(ACSL)
Ligase
| Full Name | Long-chain-fatty-acid--CoA ligase |
|---|---|
| Subcellular Location | Cell membrane Cytoplasm Cytoplasmic vesicle Endoplasmic reticulum Endoplasmic reticulum membrane Membrane Microsome Microsome membrane Mitochondrion Mitochondrion outer membrane Multi-pass membrane protein Peripheral membrane protein Peroxisome membrane Single-pass type III membrane protein |
| EC numbers | 6.2.1.3 |
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Perhexiline | 200 μM | mouse; Crl/CD-l(1CR)BR Swiss | liver mitochondria | Measurement of activity of long-chain fatty acyl-CoA synthetase | Negative | p < 0.05 | 193 | |
| Troglitazone | Positive | 227 | ||||||
| Perhexiline | 400 μM | mouse; Crl/CD-l(1CR)BR Swiss | liver mitochondria | Measurement of activity of long-chain fatty acyl-CoA synthetase | Negative | p < 0.05 | 193 | |
T027001. Long-chain-fatty-acid--CoA ligase 1
T027002. Long-chain-fatty-acid--CoA ligase 3
T027003. Long-chain-fatty-acid--CoA ligase 4
T027004. Long-chain-fatty-acid--CoA ligase 5
T027005. Long-chain-fatty-acid--CoA ligase 6
T027006. Long-chain-fatty-acid--CoA ligase ACSBG1
T027007. Long-chain-fatty-acid--CoA ligase ACSBG2
T027008. Very long-chain acyl-CoA synthetase
T027002. Long-chain-fatty-acid--CoA ligase 3
T027003. Long-chain-fatty-acid--CoA ligase 4
T027004. Long-chain-fatty-acid--CoA ligase 5
T027005. Long-chain-fatty-acid--CoA ligase 6
T027006. Long-chain-fatty-acid--CoA ligase ACSBG1
T027007. Long-chain-fatty-acid--CoA ligase ACSBG2
T027008. Very long-chain acyl-CoA synthetase