T234 Source: Uniprot
enzymeDNA polymerase gamma
(PolG)
| Full Name | DNA polymerase gamma |
|---|---|
| Subcellular Location | Mitochondrion Mitochondrion matrix, mitochondrion nucleoid |
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Emtricitabine | Positive | 194 | ||||||
| Menadione | 6.0 μM | 1 hours | human | pFastBac | Meassurement of DNA polymerase gamma activity | Positive | IC50 | 9 |
| phylloquinone | >200 μM | 1 hours | human | pFastBac | Meassurement of DNA polymerase gamma activity | Negative | IC50 | 9 |
| menaquinones | >200 μM | 1 hours | human | pFastBac | Meassurement of DNA polymerase gamma activity | Negative | IC50 | 9 |
| Zalcitabine | Positive | 194 | ||||||
| Didanosine | Positive | 194 | ||||||
| Stavudine | Positive | 194 | ||||||
| Lamivudine | Positive | 194 | ||||||
| Tenofovir | Positive | 194 | ||||||
| Zidovudine | Positive | 194 | ||||||
| Carbovir | Positive | 194 | ||||||
| Abacavir | Positive | 194 | ||||||
| Fialuridine | Positive | 194 | ||||||