T358 Source: Uniprot
enzymeDynamin-1-like protein
(Drp1)
Hydrolase
| Full Name | Dynamin-1-like protein |
|---|---|
| Protein Names | Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) |
| Subcellular Location | Cytoplasm, cytosol Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Endomembrane system Golgi apparatus Membrane, clathrin-coated pit Mitochondrion outer membrane Peripheral membrane protein Peroxisome |
| EC numbers | 3.6.5.5 |
| Uniprot Accession | O00429 |
| Uniprot Name | DNM1L_HUMAN |
| Gene symbol | DNM1L |
| Gene Name | Dynamin 1 like |
| Ensembl | ENSG00000087470 |
| Compound | Dose | Time | Species | Model | Method | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Mdivi-1 | Positive | 248 | ||||||
| P110 | 1 µM | 2hr | SH-SY5Y cells were treated with P110 (1 µM) followed by incubation of MPP+ (2 mM) for 2 hours. | Mitochondrial superoxide production was determined using the mitochondrial superoxide indicator MitoSOX Red. Total ROS production was determined in SH-SY5Y cells using CM2-HDCFA. | Positive | 310 | ||
| Mdivi-1 | Positive | 296 | ||||||
| P110 | 1 µM | 30min | Cultured SH-SY5Y cells incubated with MPP+ (2 mM, for 4 hours) or CCCP (5 µM, for 30 minutes). The cells were then stained with anti-Tom20 antibody (green) and Hoechst stain. | microscopy images | Positive | 310 | ||