F030603 | Fragmentation

Compound Dose Time Species Model Method Action Result Positive criterion Reference
MG-132 20 μM 6 hr HeLa cells The cells were stained with MitoTracker Green FM and MitoSOX Red dyes followed by image acquisition on a confocal microscope. induce Positive 291
Niclosamide 1, 5, and 10 uM 3 hr (1.5-6hr) HeLa/mito-YFP fluorescence microscope induce Positive 294
Diazepam 140μg/ml 16hr PE cells Energy-dependent accumulation of ethylrhodamine ; Electron micrographs of ultrathin sections induce Positive 293
P110 1 µM 30min Cultured SH-SY5Y cells incubated with MPP+ (2 mM, for 4 hours) or CCCP (5 µM, for 30 minutes). The cells were then stained with anti-Tom20 antibody (green) and Hoechst stain. microscopy images inhibit Positive 310
BGP-15 50 μM 4hr WRL-68 cells mERFP-labeled WRL-68 cells reduce Positive 297
H2O2 10 μmol/10E7 cells 4-6hr C2C12 mouse muscle myoblasts detected by either MitoTracker Red staining, or by mERFP transfection induce Positive 297