T358 Source: Uniprot

enzymeDynamin-1-like protein (Drp1)
Full Name Dynamin-1-like protein
Protein Names Dynamin-1-like protein (EC (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1)
Subcellular Location Cytoplasm, cytosol Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Endomembrane system Golgi apparatus Membrane, clathrin-coated pit Mitochondrion outer membrane Peripheral membrane protein Peroxisome
EC numbers
Uniprot Accession O00429
Uniprot Name DNM1L_HUMAN
Gene symbol DNM1L
Gene Name Dynamin 1 like
Ensembl ENSG00000087470

Compound Dose Time Species Model Method Result Positive criterion Reference
Mdivi-1 Positive 248
P110 1 µM 2hr SH-SY5Y cells were treated with P110 (1 µM) followed by incubation of MPP+ (2 mM) for 2 hours. Mitochondrial superoxide production was determined using the mitochondrial superoxide indicator MitoSOX Red. Total ROS production was determined in SH-SY5Y cells using CM2-HDCFA. Positive 310
Mdivi-1 Positive 296
P110 1 µM 30min Cultured SH-SY5Y cells incubated with MPP+ (2 mM, for 4 hours) or CCCP (5 µM, for 30 minutes). The cells were then stained with anti-Tom20 antibody (green) and Hoechst stain. microscopy images Positive 310