F0306 | Shape

Compound Dose Time Species Model Method Action Result Positive criterion Reference
sertraline Change Positive 307
Fluoxetine Change Positive 307
Clozapine Positive 197
Troglitazone 25 µM HepG2 cells Images from transmission electron microscopy abnormal Positive 332
MG-132 20 μM 6 hr HeLa cells The cells were stained with MitoTracker Green FM and MitoSOX Red dyes followed by image acquisition on a confocal microscope. induce Positive 291
Hydrazine 2 mM 22-24 h primary culture rat hepatocytes, RL-34(JCRB 0247), COS-1(JCRB 9082) IAR-20(JCRB 0610) induce Positive 292
H2O2 0.2mM 22hr rimary culture rat hepatocytes, RL-34,COS-1, IAR-20 induce Positive 292
Chloramphenicol 200-300µg/ml 22hr primary culture rat hepatocytes, RL-34,COS-1, IAR-20 induce Positive 292
Ethidium Bromide 200-300 µg/ml, 2 22h RL-34, COS-1, IAR-20L cells (mouse fibrob-lasts) induce Positive 292
Erythromycin 200 µg/ml 22 h primary culture rat hepatocytes, RL-34,COS-1, IAR-20 induce Positive 292
Indomethacin 0.3-0.5 mM 22 h primary culture rat hep-atocytes, RL-34,COS-1, IAR-20 induce Positive 292
Cisplatin Positive 197
Ethanol 12.5-500 mM 5min rat cardiac myocytes induce Positive 292
Niclosamide 1, 5, and 10 uM 3 hr (1.5-6hr) HeLa/mito-YFP fluorescence microscope induce Positive 294
Ethanol 1-3% 6hr RL-34 induce Positive 292
Diazepam 140μg/ml 16hr PE cells Energy-dependent accumulation of ethylrhodamine ; Electron micrographs of ultrathin sections induce Positive 293
P110 1 µM 30min Cultured SH-SY5Y cells incubated with MPP+ (2 mM, for 4 hours) or CCCP (5 µM, for 30 minutes). The cells were then stained with anti-Tom20 antibody (green) and Hoechst stain. microscopy images inhibit Positive 310
tacrolimus beta cells from isolated rat islets Transmission electron microscopy and 3D reconstruction of mitochondria decrease Positive 322
BGP-15 50 μM 4hr WRL-68 cells mERFP-labeled WRL-68 cells reduce Positive 297
H2O2 10 μmol/10E7 cells 4-6hr C2C12 mouse muscle myoblasts detected by either MitoTracker Red staining, or by mERFP transfection induce Positive 297