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Compound

D0421 | 2‐Butylbenzofuran

Molecular Formula C12H14O
Molecular Weight 174.24
Structure

Toxicity Dose Time Species Model Method Action Positive criterion Reference
UNCOUPLING 1 μmol/L rat; Sprague–Dawley hepatocytes Measurement of oxygen uptake Negative p < 0.05 4
UNCOUPLING 10 μmol/L rat; Sprague–Dawley hepatocytes Measurement of oxygen uptake Negative p < 0.05 4
UNCOUPLING 20 μmol/L rat; Sprague–Dawley hepatocytes Measurement of oxygen uptake Negative p < 0.05 4
UNCOUPLING 50 μmol/L rat; Sprague–Dawley hepatocytes Measurement of oxygen uptake Negative p < 0.05 4
UNCOUPLING 80 μmol/L rat; Sprague–Dawley hepatocytes Measurement of oxygen uptake Negative p < 0.05 4
UNCOUPLING 100 μmol/L rat; Sprague–Dawley hepatocytes Measurement of oxygen uptake Negative p < 0.05 4
MEMBRANE POTENTIAL 0.5 μmol/L 1 hour rat; Sprague–Dawley hepatocytes Measurement of mitochondrial membrane potential Negative p < 0.05 4
MEMBRANE POTENTIAL 1 μmol/L 1 hour rat; Sprague–Dawley hepatocytes Measurement of mitochondrial membrane potential Negative p < 0.05 4
MEMBRANE POTENTIAL 4 μmol/L 1 hour rat; Sprague–Dawley hepatocytes Measurement of mitochondrial membrane potential Negative p < 0.05 4
MEMBRANE POTENTIAL 8 μmol/L 1 hour rat; Sprague–Dawley hepatocytes Measurement of mitochondrial membrane potential Negative p < 0.05 4
MEMBRANE POTENTIAL 20 μmol/L 1 hour rat; Sprague–Dawley hepatocytes Measurement of mitochondrial membrane potential Negative p < 0.05 4
STATE 3 RESPIRATION 10 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake Negative p < 0.05 4
STATE 3 RESPIRATION 20 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake Negative p < 0.05 4
STATE 3 RESPIRATION 50 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake Negative p < 0.05 4
STATE 3 RESPIRATION 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake Negative p < 0.05 4
STATE 3 RESPIRATION 10 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake Negative p < 0.05 4
STATE 3 RESPIRATION 20 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake Negative p < 0.05 4
STATE 3 RESPIRATION 50 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake Negative p < 0.05 4
STATE 3 RESPIRATION 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake Negative p < 0.05 4
STATE 3 RESPIRATION 10 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake Negative p < 0.05 4
STATE 3 RESPIRATION 20 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake Negative p < 0.05 4
RESPIRATORY CONTROL RATIO (RCR) 10 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake Negative p < 0.05 4
RESPIRATORY CONTROL RATIO (RCR) 20 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake Negative p < 0.05 4
RESPIRATORY CONTROL RATIO (RCR) 50 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease p < 0.05 4
RESPIRATORY CONTROL RATIO (RCR) 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease p < 0.01 4
RESPIRATORY CONTROL RATIO (RCR) 50 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake Negative p < 0.05 4
RESPIRATORY CONTROL RATIO (RCR) 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of oxygen uptake decrease p < 0.01 4
MITOCHONDRIAL FATTY ACID BETA OXIDATION 10 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation Negative p < 0.05 4
MITOCHONDRIAL FATTY ACID BETA OXIDATION 20 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation Negative p < 0.05 4
MITOCHONDRIAL FATTY ACID BETA OXIDATION 50 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation Negative p < 0.05 4
MITOCHONDRIAL FATTY ACID BETA OXIDATION 80 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation Negative p < 0.05 4
MITOCHONDRIAL FATTY ACID BETA OXIDATION 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease p < 0.01 4
MITOCHONDRIAL FATTY ACID BETA OXIDATION 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of acyl‐CoA dehydrogenase activity decrease 22% inhibition 4
MITOCHONDRIAL FATTY ACID BETA OXIDATION 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of β‐ketothiolase activity Negative no inhibition 4
SYNTHESIS OF KETONE BODY 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of beta oxidation and ketone body formation decrease 28% inhibition 4
SWELLING 1 μmol/L rat; Sprague–Dawley liver mitochondria Measurements of mitochondrial swelling Negative p < 0.05 4
SWELLING 10 μmol/L rat; Sprague–Dawley liver mitochondria Measurements of mitochondrial swelling Negative p < 0.05 4
SWELLING 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurements of mitochondrial swelling Negative p < 0.05 4
OXIDATIVE STRESS 0.1 μmol/L 1 hour human HepG2 Measurement of ROS Negative p < 0.05 4
OXIDATIVE STRESS 1 μmol/L 1 hour human HepG2 Measurement of ROS Negative p < 0.05 4
OXIDATIVE STRESS 100 μmol/L 1 hour human HepG2 Measurement of ROS Negative p < 0.05 4
APOPTOSIS 100 μmol/L 8 hours human HepG2 Assessment of cytochrome c release Negative observable 4
LATE APOPTOSIS 100 μmol/L 8 hours rat; Sprague–Dawley hepatocytes Apoptosis measurement Negative p < 0.05 4
LATE APOPTOSIS 1 μmol/L 8 hours rat; Sprague–Dawley hepatocytes Apoptosis measurement Negative p < 0.05 4
LATE APOPTOSIS 100 μmol/L 8 hours rat; Sprague–Dawley hepatocytes Apoptosis measurement Negative p < 0.05 4

Target Dose Time Species Model Method Action Positive criterion Reference
3-ketoacyl-CoA thiolase, mitochondrial 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of β‐ketothiolase activity Negative no inhibition 4
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial 100 μmol/L rat; Sprague–Dawley liver mitochondria Measurement of acyl‐CoA dehydrogenase activity inhibitor 22% inhibition 4
Cytochrome c 100 μmol/L 8 hours human HepG2 Assessment of cytochrome c release Negative observable 4

Pictogram Signal Statements Precautionary Statement Codes

Aggregated GHS information provided by 44 companies from 2 notifications to the ECHA C&L Inventory.


Reported as not meeting GHS hazard criteria by 6 of 44 companies. For more detailed information, please visit ECHA C&L website


Of the 1 notification(s) provided by 38 of 44 companies with hazard statement code(s):


H413 (100%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]


Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.


 P273, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.)


  • 2-Butyl-1-benzofuran 2-Butyl-1-benzofuran # 2-Butyl-benzofuran
    2-Butylbenzofuran 2-butyl benzo[b]furan 2-butyl benzofuran
    2-butylbenzo[b]furan 2-n-Butylbenzo[b]furan 2-n-Butylbenzofuran
    2-n-Butylbezofuran 2-n-butyl-benzofuran 2-n-butylbenzofurane
    4265-27-4 A825975 AC-18725
    ACMC-1ANWT AKOS009031452 ANW-29855
    AS-56882 Benzofuran, 2-butyl- Butyl-2-benzofuran
    CTK1D8137 DB-050954 DTXSID90195378
    EINECS 224-250-7 FT-0611635 InChI=1/C12H14O/c1-2-3-7-11-9-10-6-4-5-8-12(10)13-11/h4-6,8-9H,2-3,7H2,1H3
    MCULE-3407406765 MFCD00005851 NE10411
    OVJKFJDEVKABNF-UHFFFAOYSA- OVJKFJDEVKABNF-UHFFFAOYSA-N RTC-063842
    SC-17544 SCHEMBL1287509 ST24032425
    ST50407981 TC-063842 W-106267
    Z1250132589 ZINC2141025 butylbenzofuran

    CAS Number 4265-27-4
    PubChem Compound 77951
    ChemSpider 70341