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Drug

D0458 | buformin

Molecular Formula C6H15N5
Molecular Weight 157.22
Structure
State solid
Description anti-diabetic drug of the biguanide class

A

A10BA03 Buformin


[A10BA] Biguanides


[A10B] BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS


[A10] DRUGS USED IN DIABETES


[A] Alimentary tract and metabolism

Toxicity Dose Time Species Model Method Action Positive criterion Reference
MEMBRANE POTENTIAL 75 μM 24 hours human hepatocytes Measurement of mitochondrial membrane potential decrease 15
STATE 2 RESPIRATION 100 nmol/mg mitochondrial protein rat; Sprague–Dawley liver mitochondria Meassurement of respiration decrease 15
STATE 2 RESPIRATION 100 nmol/mg mitochondrial protein 40 minutes preincubation rat; Sprague–Dawley liver mitochondria Meassurement of respiration decrease 15
STATE 3 RESPIRATION 100 nmol/mg mitochondrial protein rat; Sprague–Dawley liver mitochondria Meassurement of respiration decrease 15
STATE 3 RESPIRATION 100 nmol/mg mitochondrial protein 40 min preincubation rat; Sprague–Dawley liver mitochondria Meassurement of respiration decrease 15
OXYGEN CONSUMPTION RATE (OCR) 25 μM 24 hours human HepG2 cells Measurement of OCR decrease p < 0.001 15
ELECTRON TRANSPORT CHAIN 11.3 mM Bovine heart mitochondria Measurement of complex I activity decrease IC50 15
ECAR 25 μM 24 hours human HepG2 cells Measurement of ECAR increase p < 0.001 15
ATP SYNTHESIS 62.5 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease p < 0.001 15
ATP SYNTHESIS 62.5 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease p < 0.001 15
ATP SYNTHESIS 26.1 μM 24 hours human hepatocytes Assay of Cellular ATP Content decrease IC50 15
ATP SYNTHESIS 43.7 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease IC50 15
ATP SYNTHESIS > 500 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease IC50 15
OXIDATIVE STRESS 75 μM 24 hours human hepatocytes ROS measurement increase 15
OXIDATIVE STRESS 75 μM 24 hours human hepatocytes Measurement of mitochondrial membrane potential affect 15

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase 11.3 mM Bovine heart mitochondria Measurement of complex I activity inhibitor IC50 15
ATP 62.5 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease p < 0.001 15
ATP 62.5 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease p < 0.001 15
ATP 26.1 μM 24 hours human hepatocytes Assay of Cellular ATP Content decrease IC50 15
ATP 43.7 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease IC50 15
ATP > 500 μM 24 hours human HepG2 cells Assay of Cellular ATP Content decrease IC50 15
Reactive oxygen species 75 μM 24 hours human hepatocytes ROS measurement increase 15
oxidized glutathione 75 μM 24 hours human hepatocytes Measurement of mitochondrial membrane potential decrease 15


  • ((1E)-1-amino-2-azahex-1-enyl)aminocarboxamidine 1-Butylbiguanide 1-Butyldiguanide
    1-butyl-3-carbamimidoyl-guanidine 1-n-butylbiguanide 179391-EP2275108A1
    2-butyl-1-(diaminomethylene)guanidine 2-butyl-1-(diaminomethylidene)-guanidine 4-04-00-00582 (Beilstein Handbook Reference)
    692-13-7 96642-EP2287163A1 96642-EP2305678A1
    AKOS003382834 AKOS006228752 ALBB-023188
    Adebit Andere BIGUANIDE, 1-BUTYL-
    BRN 0607037 Biforon Biguanide, 1-butyl-, hydrochloride
    Buformin Buformin (USAN/INN) Buformin HCl
    Buformin [USAN:INN] Buformina Buformina [INN-Spanish]
    Buformine Buformine HCl Buformine [INN-French]
    Buforminum Buforminum [INN-Latin] Butformin
    Butyl guanylguanidine Butylbiguanid Butylbiguanide
    Butylbiguanide hydrochloride Butylbiguanidum Butyldiguanide
    C07674 C6H15N5 CAS-692-13-7
    CHEBI:3209 CHEMBL39736 CTK2F2993
    D00595 DB04830 DBV
    DBV hydrochloride DSSTox_CID_26420 DSSTox_GSID_46420
    DSSTox_RID_81598 DTXSID6046420 Diabrin
    EINECS 211-726-4 Glybigid Glybigidum
    H 224 Imidodicarbonimidic diamide, N-butyl- Imidodicarbonimidic diamide, N-butyl-, hydrochloride
    Imidodicarbonimidicdiamide, N-butyl- LS-43858 MCULE-5413481004
    N,n-butylbiguanide N-Butylbiguanide N-Butyldicarbonimido/ic diamide/imido
    N-butyl-1-carbamimidamidomethanimidamide N-butylimidodicarbonimidic diamide N1-Butylbiguanide
    NCGC00164533-01 NCGC00164533-02 NCGC00186641-01
    NSC113665 Panformin Q715104
    SB 103 SBB056560 SCHEMBL15762988
    SCHEMBL27451 SR-01000944701 SR-01000944701-1;
    ST088005 STL484281 Sindiatil
    Tox21_112164 Tox21_112164_1 UNII-W2115E9C7B
    W 37 W2115E9C7B XSEUMFJMFFMCIU-UHFFFAOYSA-N
    ZINC4097425 amino[(butylamino)iminomethyl]carboxamidine n-Butylbiguanidine

    DrugBank Name buformin
    DrugBank DB04830
    CAS Number 1190-53-0, 15537-73-2, 692-13-7
    PubChem Compound 2468
    KEGG Compound ID C07674
    KEGG Drug D00595
    ChEBI 3209