D0459 | promethazine
D
V
R
V03AB05 Prednisolone and promethazine
[V03AB] Antidotes
[V03A] ALL OTHER THERAPEUTIC PRODUCTS
[V03] ALL OTHER THERAPEUTIC PRODUCTS
[V] Various ATC structures
R06AD52 Promethazine, combinations
[R06AD] Phenothiazine derivatives
[R06A] ANTIHISTAMINES FOR SYSTEMIC USE
[R06] ANTIHISTAMINES FOR SYSTEMIC USE
[R] Respiratory system
R06AD02 Promethazine
[R06AD] Phenothiazine derivatives
[R06A] ANTIHISTAMINES FOR SYSTEMIC USE
[R06] ANTIHISTAMINES FOR SYSTEMIC USE
[R] Respiratory system
D04AA10 Promethazine
[D04AA] Antihistamines for topical use
[D04A] ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
[D04] ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
[D] Dermatological drugs
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| STATE 3 RESPIRATION | Negative | 22 | ||||||
| STATE 4 RESPIRATION | increase | 22 | ||||||
| ELECTRON TRANSPORT CHAIN | decrease | 35 | ||||||
| POTASSIUM RELEASE | increase | 22 | ||||||
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Quinol--cytochrome-c reductase | inhibitor | 35 | ||||||
| potassium | not specified | 22 | ||||||
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
   |
Danger |
Aggregated GHS information provided by 53 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H318 (11.32%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H319 (16.98%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H410 (16.98%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] H411 (11.32%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P264, P270, P273, P280, P301+P312, P305+P351+P338, P310, P330, P337+P313, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| Organism | Test type | Route | Dose (normalized dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intravenous | 27mg/kg (27mg/kg) | Pharmazie. Vol. 25, Pg. 91, 1970. | |
| mouse | LD50 | oral | 326mg/kg (326mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 237, 1957. | |
| guinea pig | LD50 | intraperitoneal | 116mg/kg (116mg/kg) | Medicina Experimentalis. Vol. 8, Pg. 237, 1963. | |
| mouse | LD50 | intraperitoneal | 124mg/kg (124mg/kg) | behavioral: convulsions or effect on seizure threshold | Journal of Pharmacology and Experimental Therapeutics. Vol. 108, Pg. 201, 1953. |
| mouse | LD50 | intravenous | 40mg/kg (40mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. | |
| mouse | LD50 | intramuscular | 175mg/kg (175mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. | |
| child | TDLo | skin | 13mg/kg (13mg/kg) | Canadian Medical Association Journal. Vol. 130, Pg. 1460, 1984. | |
| dog | LDLo | oral | 500mg/kg (500mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1772, 1970. | |
| rat | LD50 | subcutaneous | 700mg/kg (700mg/kg) | Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 144, Pg. 887, 1950. | |
| guinea pig | LD50 | oral | 640mg/kg (640mg/kg) | Pharmazie. Vol. 25, Pg. 91, 1970. | |
| mouse | LD50 | subcutaneous | 225mg/kg (225mg/kg) | Produits Pharmaceutiques. Vol. 2, Pg. 53, 1947. | |
| rat | LD50 | intravenous | 45mg/kg (45mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 450, 1959. | |
| man | TDLo | intravenous | 2857ug/kg/C (2.857mg/kg) | behavioral: coma | Annals of Emergency Medicine. Vol. 24, Pg. 979, 1994. |
| rat | LD50 | intramuscular | 169mg/kg (169mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. | |
| rat | LDLo | intraperitoneal | 140mg/kg (140mg/kg) | Toxicology and Applied Pharmacology. Vol. 1, Pg. 156, 1959. | |
| guinea pig | LD50 | subcutaneous | 520mg/kg (520mg/kg) | Pharmazie. Vol. 25, Pg. 91, 1970. | |
| rabbit | LD50 | intravenous | 19mg/kg (19mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 450, 1959. | |
| rabbit | LD50 | oral | 580mg/kg (580mg/kg) | Pharmazie. Vol. 25, Pg. 91, 1970. | |
| cat | LDLo | oral | 250mg/kg (250mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1772, 1970. | |
| (.+/-.)-Promethazine | (2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine | (Dimethylamino-2-propyl-10-phenothiazine hydrochloride |
| 10-(2-(Dimethylamino)-2-methylethyl)phenothiazine | 10-(2-(Dimethylamino)propyl)phenothiazine | 10-(2-Dimethylaminopropyl)phenothiazine |
| 10-[2-(Dimethylamino)propyl]phenothiazine | 10H-Phenothiazine-10-ethanamine, N,N,.alpha.-trimethyl- | 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl- |
| 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl- (9CI) | 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, radical ion(1+) | 10H-Phenothiazine-10-ethanamine,N,.alpha.-trimethyl- |
| 10H-Phenothiazine-10-ethanamine,N,N,b-trimethyl- | 3277 RP | 3389 R.p. |
| 38878-40-9 | 4-27-00-01253 (Beilstein Handbook Reference) | 4182 R.p. |
| 60-87-7 | A-91033 | AB00053535 |
| AB00053535-12 | AB00053535_13 | AC-15939 |
| AKOS015962127 | Antiallersin | Aprobit |
| Atosil | Avomine | BDBM50017696 |
| BPBio1_000744 | BRN 0088554 | BSPBio_000676 |
| BSPBio_002777 | C07404 | CAS-60-87-7 |
| CCG-109848 | CCRIS 7056 | CHEBI:8461 |
| CHEMBL643 | CTK1C4979 | Camergan |
| D00494 | DB01069 | DSSTox_CID_3518 |
| DSSTox_GSID_23518 | DSSTox_RID_77061 | DTXSID7023518 |
| Dimapp | Dimethylamino-isopropyl-phenthiazin | Dimethylamino-isopropyl-phenthiazin [German] |
| Diphergan | Diprazine | Diprozin |
| DivK1c_000005 | EINECS 200-489-2 | EX-A891 |
| FF28EJQ494 | FT-0700342 | Fargan |
| Fenazil | Fenetazina | Fenetazine |
| GTPL7282 | HMS2089E08 | HSDB 3173 |
| Hiberna | Histargan | IDI1_000005 |
| Iergigan | InChI=1/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3; | Isophenergan |
| J-690333 | KBio1_000005 | KBio2_001348 |
| KBio2_003916 | KBio2_006484 | KBio3_001997 |
| KBioGR_001697 | KBioSS_001348 | L000495 |
| LS-264 | Lercigan | Lilly 01516 |
| Lilly 1516 | Lopac0_000899 | MCULE-8146430046 |
| Metaryl | N,N,alpha-Trimethyl-10H-phenothiazine-10-ethanamine | N,N-DIMETHYL-1-PHENOTHIAZIN-10-YL-PROPAN-2-AMINE |
| N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine | N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine # | N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine |
| N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine | N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine hydrochloride | N-(2'-Dimethylamino-2'-methyl)ethylphenothiazine |
| N-Dimethylamino-2-methylethyl thiodiphenylamine | NCGC00015817-03 | NCGC00015817-04 |
| NCGC00015817-05 | NCGC00015817-06 | NCGC00015817-08 |
| NCGC00015817-09 | NCGC00015817-10 | NCGC00015817-11 |
| NCGC00015817-12 | NCGC00015817-14 | NCGC00089735-02 |
| NCGC00089735-03 | NCI-C60673 | NCI60_001878 |
| NINDS_000005 | NSC 30321 | NSC-30321 |
| NSC30321 | Oprea1_758749 | PROMETHAZINE (SEE ALSO PROMETHAZINE HYDROCHLORIDE 58-33-3) |
| PWWVAXIEGOYWEE-UHFFFAOYSA- | PWWVAXIEGOYWEE-UHFFFAOYSA-N | Pelpica |
| Phargan | Phenargan | Phenergan base |
| Phenerzine | Phenoject-50 | Phenothiazine, 10-(2-dimethylaminopropyl)- |
| Phenothiazine, 10-[2-(dimethylamino)propyl]- | Phensedyl | Pilothia |
| Pilpophen | Pipolphen (Salt/Mix) | Pipolphene |
| Prestwick0_000888 | Prestwick1_000888 | Prestwick2_000888 |
| Prestwick3_000888 | Pro-50 | Proazaimine |
| Proazamine | Procit | Promacot |
| Promazinamide | Promergan | Promesan |
| Prometasin | Prometazin | Prometazina |
| Prometazina [INN-Spanish] | Prometazine | Prometh |
| Promethacon | Promethazin | Promethazine (JAN/INN) |
| Promethazine [INN:BAN] | PromethazineHcl | Promethazinum |
| Promethazinum [INN-Latin] | Promethegan | Promethiazine |
| Promezathine | Prorex | Protazine |
| Prothazin | Prothazine | Provigan |
| Pyrethia | Pyrethia (Salt/Mix) | Pyrethiazine |
| Q422970 | RP 3277 | RP-3277 |
| Remsed (Salt/Mix) | Rumergan | SBI-0050874.P004 |
| SCHEMBL4700 | SKF 1498 | SPBio_000799 |
| SPBio_002895 | SR-01000002993 | SR-01000002993-10 |
| Sominex | Spectrum2_000840 | Spectrum3_001019 |
| Spectrum4_001149 | Spectrum5_000977 | Spectrum_000868 |
| Tanidil | Thiergan | Tox21_110227 |
| Tox21_110227_1 | UNII-FF28EJQ494 | Valergine |
| Vallergine | WLN: T C666 BN ISJ B1Y1&N1&1 | WY 509 |
| dimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine | promethazine |