D0545 | famoxadone
| Toxicity | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| MEMBRANE POTENTIAL | 4.19±1.07 | human | qHTS-HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 4.47 | human | HepG2 | MMP assay | decrease | IC50 | 163 | |
| MEMBRANE POTENTIAL | 8.38±6.71 | rat | hepatocytes | MMP assay | decrease | IC50 | 163 | |
| ELECTRON TRANSPORT CHAIN | 100 mM | incubated overnight | bovine | isolated heart mitochondria | Measurements of redox potentials of the ISP | affect | 83 | |
| Target | Dose | Time | Species | Model | Method | Action | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|
| Qo site (Qp site or ubiquinol oxidation site) | 100 mM | incubated overnight | bovine | isolated heart mitochondria | Measurements of redox potentials of the ISP | fixed conformation | 83 | |
| Pictogram | Signal | Statements | Precautionary Statement Codes |
|---|---|---|---|
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Warning |
H373 **: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P260, P273, P314, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Warning |
Aggregated GHS information provided by 224 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. H373 (100%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] H400 (94.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. |
P260, P273, P314, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
|
|
Warning |
H373: Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
P260, P273, P314, P391, and P501; (The corresponding statement to each P-code can be found at the GHS Classification page.) |
| 131807-57-3 | 2,4-Oxazolidinedione, 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)- | 2,4-Oxazolidinedione,5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)- |
| 3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione | 486-EP2274983A1 | 486-EP2305662A1 |
| 486-EP2308857A1 | 486-EP2314583A1 | 5-METHYL-5-(4-PHENOXYPHENYL)-3-(PHENYLAMINO)-2,4-OXAZOLIDINEDIONE |
| 5-Methyl-5-(4-phenoxyphenyl)-3-(phenylamino)oxazolidine-2,4-dione | 5-Methyl-5-(4-phenoxyphenyl)-3-phenylamino-2,4-oxazolidinedione | 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-1,3-oxazolidine-2,4-dione |
| 807F573 | ACMC-20car7 | AKOS015917628 |
| AS-35178 | BCP10368 | C-21219 |
| CAS-131807-57-3 | CC-28351 | CHEBI:83250 |
| CHEMBL1812200 | CTK4B7532 | DB-042062 |
| DPX-JE 874 | DPX-JE874 pound>>DPX JE874 pound>>Famoxadon pound>>Famoxate | DSSTox_CID_14588 |
| DSSTox_GSID_34588 | DSSTox_RID_79172 | DTXSID8034588 |
| FMX | FT-0631140 | Famoxadone |
| Famoxadone 10 microg/mL in Cyclohexane | Famoxadone [ISO:BSI] | Famoxadone solution |
| Famoxadone solution, 100 ng/muL in acetonitrile, PESTANAL(R), analytical standard; | Famoxate | HSDB 7266 |
| J-006058 | LS-100368 | NCGC00168306-01 |
| NCGC00168306-02 | NCGC00168306-03 | NCGC00255042-01 |
| PCCSBWNGDMYFCW-UHFFFAOYSA-N | Q412776 | RTR-031747 |
| SCHEMBL63351 | TR-031747 | Tox21_301144 |
| DrugBank Name | famoxadone |
| DrugBank | DB07778 |
| CAS Number | 131807-57-3, 15316-91-3 |
| PubChem Compound | 213032 |
| KEGG Compound ID | C18591 |
| ChEBI | 59340 |