Search References Drug Actions/Targets About Access data Feedback
Sign In
mitontu@gmail.com
2021 MitoTox | (CC BY-NC 4.0)
Compound

D0562 | ossamycin

Molecular Formula C49H85NO14
Molecular Weight 912.2
Structure
Description polyketide inhibitors of F0F1-ATPase; antifungal; cytotoxic; polyketide; a potent inhibitor of the F0 component of mitochondrial F1F0-ATPase

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTRON TRANSPORT CHAIN 46 μg of inhibitor/mg protein E. coli pH gradient formation by membrane vesicle affect IC50 170
ELECTRON TRANSPORT CHAIN 8 μM human NCI-60 cell lines F0F1-ATPase affect IC50 170
ELECTRON TRANSPORT CHAIN 1.3 μg of inhibitor/mg protein S. cerevisiae SMP-ATPase affect IC50 170
ELECTRON TRANSPORT CHAIN 1.3 μg of inhibitor/mg protein S. cerevisiae SMP-ATPase decrease IC50 153
ELECTRON TRANSPORT CHAIN 46 μg of inhibitor/mg protein E. coli membrane vesicle decrease IC50 152
ELECTRON TRANSPORT CHAIN 8 μM human NCI-60 cell lines, F0F1-ATPase decrease IC50 154
ELECTRON TRANSPORT CHAIN 0.8 μM 60 human cancer cell lines of the National Cancer Institute decrease mean 184

Target Dose Time Species Model Method Action Positive criterion Reference
ATP synthase 1.3 μg of inhibitor/mg protein S. cerevisiae SMP-ATPase inhibitor IC50 153
ATP synthase 46 μg of inhibitor/mg protein E. coli membrane vesicle inhibitor IC50 152
ATP synthase 8 μM human NCI-60 cell lines, F0F1-ATPase inhibitor IC50 154
ATP synthase 0.8 μM 60 human cancer cell lines of the National Cancer Institute inhibitor mean 184
Fo subunits 46 μg of inhibitor/mg protein E. coli pH gradient formation by membrane vesicle inhibitor IC50 170
Fo subunits 8 μM human NCI-60 cell lines F0F1-ATPase inhibitor IC50 170
Fo subunits 1.3 μg of inhibitor/mg protein S. cerevisiae SMP-ATPase inhibitor IC50 170


  • Antibiotic B 61,893 B 61893K621; CHEMBL1713335
    MLS002702998 NSC-76627 NSC76627
    Ossamycin SMR001566807

    PubChem Compound 5351598
    ChEBI 77735