MITOTOX

Compound

D1425 | BGP-15

Properties

Molecular Formula	C14H24Cl2N4O2
Molecular Weight	351.3
Structure
Description	hydroxylamine derivative; PARP inhibitor and insulin sensitizer; prevents insulin resistance in humans and protects against several oxidative stress-related diseases

Therapeutic Classification Source: DrugBank

Mitochondrial Toxicity Evaulation

Toxicity	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
FRAGMENTATION	50 μM	4hr		WRL-68 cells	mERFP-labeled WRL-68 cells	reduce		297
FUSION	50 μM	4hr		WRL-68 cells	Polyethylene glycol (PEG) fusion assay; OPA1 GTPase assay and OPA1-OPA1 interactions	induce		297

Targets

Target	Dose	Time	Species	Model	Method	Action	Positive criterion	Reference
Dynamin-like 120 kDa protein, mitochondrial	50 μM	4hr		WRL-68 cells	Polyethylene glycol (PEG) fusion assay; OPA1 GTPase assay and OPA1-OPA1 interactions	activate		297

Indications Source: SIDER

Synonyms Source: PubChem

N-[2-hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride

External IDs

CAS Number	66611-37-8
PubChem Compound	9884807

References