Compound	Dose	Time	Species	Model	Method	Result	Positive criterion	Reference
lovastatin				C2C12 myoblasts		Positive		180
Simvastatin				C2C12 myoblasts		Positive		180
Indomethacin						Positive		162
Doxorubicin						Positive		162
Diazoxide						Positive		162
Diazoxide				Homogenates of isolated pancreatic islets; homogenates of whole pancreas, liver, heart, or skeletal muscle	The activity of the rnitochondrial glycerol phosphate dehydrogenase was assayed with a timed assay using iodonitrotetrazolium violet as an electron acceptor and in a continuous spectrophotometric assay using dichloroindophenol as an electron acceptor. acceptor. Glycerol phosphate oxidation by islet intact mitochondria was estimated from the tritiated water released from [2- 3H]glycerol phosphate	Positive		187
glyceraldehyde 3-phosphate	2.5mM					Positive		162
dihydroxyacetone phosphate						Positive		162
glyceraldehyde 3-phosphate	2.5mM					Positive		162
dihydroxyacetone phosphate						Positive		162
1h-benzimidazol-5-amine-2-4-aminophenyl	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-(Dimethylamino)-1,3-benzothiazol-6-ol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)amino]phenol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
7,8-Dihydroxy-4-methylcoumarin	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-Amino-2-(5-ethyl-benzooxazol-2-yl)-phenol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
(4-Methoxyphenyl)-[2-(p-anisidino)ethyl]amine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
3,3'-Diamino-4,4'-dihydroxydiphenyl Sulfone	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-(4-Hydroxy-1H-indol-3-yl)acetamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2,5-Bis(2-phenylacetamido)terephthalic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2,6-Dimethyl-5,12-dihydroindolo[3,2-d][1,3]benzodiazepine;hydrochloride	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
N-(4-{[(4,6-Dimethyl-2-pyrimidinyl)amino]sulfonyl}phenyl)-2,4-dimethoxybenzamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
N'-(4-Methoxybenzyl)-N,N-dimethylbenzene-1,3-diamine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-(1,2,3,4-Tetrahydro-benzo[a]phenanthridin-5-yl)-benzene-1,2-diol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
N-Benzyl-4-methoxyaniline	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
Methyl 2-amino-4-ethyl-5-methylthiophene-3-carboxylate	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
N-(4-(4-Methyl-1-piperazinyl)phenyl)-9-acridinamine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-Chloro-N-(2-hydroxyphenyl)benzenesulfonamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
N-(4-Hydroxyphenyl)furan-2-carboxamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
(Z)-2-Cyano-3-(3-ethoxy-4-hydroxyphenyl)prop-2-enamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
(3-Bromo-4-hydroxyphenyl)[(4-chlorophenyl)sulfonyl]amine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-Chloro-6-methylindolo[1,2-c]quinazolin-12-amine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-(2,3-Dihydro-1H-benzo[f]cyclopenta[c]quinolin-4-yl)benzene-1,2-diol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
(5E)-5-(4-Hydroxybenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
8-Chloro-2,2-dimethyl-2,3-dihydro-1H-phenothiazin-4(10H)-one	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-[(3,4-Dimethylphenyl)sulfonyl]benzene-1,4-diol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-([4-(1H-Benzimidazol-2-yl)phenyl]amino)-4-oxobutanoic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
Ethyl 2-ethoxy-5-hydroxy-1H-indole-3-carboxylate	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-(1,2,3,4-Tetrahydrobenzo[a]phenanthridin-5-yl)benzene-1,3-diol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
N-(Cyclohexylmethyl)-4-methoxyaniline	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
N-(Furan-2-ylmethyl)-1,3-benzodioxol-5-amine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
5-Nitro-2-phenyl-1H-indole	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
8-Chloro-2,3-dihydro-1H-phenothiazin-4(10H)-one	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
N-(4-Bromophenyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-[2-(2-Aminophenyl)vinyl]-5,7-dimethylquinolin-8-ol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4,6-Dimethyl-2-phenyl-2H-pyrazolo[3,4-b]pyridin-3-ol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-Methoxy-2-[(4-piperidylpiperidyl)methyl]phenol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
N-(5-Isopropyl-1,3,4-thiadiazol-2-yl)-3-nitrobenzamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-Amino-6-ethyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
(NE)-N-[[3-[[3-[(E)-hydroxyiminomethyl]-2,4,6-trimethylphenyl]methyl]-2,4,6-trimethylphenyl]methylidene]hydroxylamine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
N-(3-Fluorophenyl)-2,4,6-tri(propan-2-yl)benzenesulfonamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-(4-Hydroxy-3-methoxybenzylidene)-1H-indene-1,3(2H)-dione	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-Furancarboxamide, N-[[(4-methoxyphenyl)amino]thioxomethyl]-	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-Amino-N-quinolin-8-yl-benzenesulfonamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
(5Z)-5-[(4-Fluorophenyl)methylidene]-1-methyl-3-phenyl-1,3-diazinane-2,4,6-trione	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-[4-(1-Adamantyl)phenoxy]-N,N-diethylethanamine;hydrochloride	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
(2Z)-2-(Acetylamino)-N-(4-hydroxyphenyl)-3-phenylprop-2-enamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
(5E)-5-[(3-Bromo-4-methoxyphenyl)methylidene]-1-phenyl-2-sulfanylidene-1,3-diazinane-4,6-dione	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
[(3-{[(4-Bromophenyl)amino]carbonyl}phenyl)thio]acetic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-[(4-Chlorobenzyl)thio]-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
1-(5-Hydroxy-2-methyl-1-phenyl-1H-indol-3-yl)ethanone	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-[(4-Ethylpiperazin-1-yl)methyl]-4-methoxyphenol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-(4-Fluorophenyl)-1,3,5-trimethyl-2,6-diphenylpiperidin-4-ol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
N-[(E)-1-[5-(4-Bromophenyl)furan-2-yl]-3-[3-(dimethylamino)propylamino]-3-oxoprop-1-en-2-yl]-4-methylbenzamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
(2Z)-3-{N-[4-(4-Chlorophenyl)phenyl]carbamoyl}prop-2-enoic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-[(E)-3-(4-Ethylpiperazin-1-yl)prop-1-enyl]-N,N-dimethylaniline	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
1,5-Dihydro-4,5-diphenyl-2H-imidazol-2-one	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-[(E)-2-(4-Chlorophenyl)ethenyl]-1-methyl-1H-benzimidazole	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-[1-Azabicyclo[2.2.2]octan-3-ylidene-[4-(dimethylamino)phenyl]methyl]-N,N-dimethylaniline;hydrochloride	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-Oxo-4-((4-(styryl)phenyl)amino)but-2-enoic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2,5-Dianilinoterephthalic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-Methoxy-N-[4-(thiazol-2-ylsulfinamoyl)-phenyl]-benzamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
3-[(3,4-Dimethylphenyl)sulfonyl]propanenitrile	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-[4-(1,3-Benzoxazol-2-yl)anilino]-4-oxobutanoic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
1-(3-Chlorophenyl)-2,3,4,5,6,7,8,8a-octahydro-1H-isoquinolin-4a-ol;hydrochloride	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
6-Methyl-2-(1,2,2,2-tetrafluoroethyl)-1H-benzimidazole	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
Ethyl 6-amino-5-cyano-2-methyl-4-(2-nitrophenyl)-4H-pyran-3-carboxylate	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
N-(2,1,3-Benzoxadiazol-4-yl)-2,2,2-trifluoroacetamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-Tert-butyl-N-(4-methylphenyl)benzamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-Methoxy-4-(morpholin-4-ylmethyl)phenol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
Bis((1E)-2-phenylvinyl)phosphinic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
1-[2-(Allyloxy)benzyl]-4-benzylpiperidine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2,5-Diaminoterephthalic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
N-(1-Adamantylcarbonyl)-N'-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)thiourea	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-(Isobutylthio)succinic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
N-{4-[Acetyl(methyl)amino]phenyl}-4-biphenylcarboxamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
4-[(E)-3-(2-Ethylpiperidin-1-yl)prop-1-enyl]-N,N-dimethylaniline	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
3-(2-Chloro-phenyl)-2-(4-(2-oxo-2H-chromen-3-YL)-thiazol-2-YL)-acrylonitrile	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
Ethyl (7Z)-2-amino-7-(hydroxyimino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-Amino-4-(3,4-dichlorophenyl)thiazole	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
5-(2-Nitrobenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
3-(4-Bromo-2-thienyl)-2-cyano-2-propenethioamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
Benzyl [(6-amino-3,5-dicyano-4-ethylpyridin-2-yl)sulfanyl]acetate	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
N-{2-[(1,3-Diphenyl-1H-pyrazol-5-yl)amino]phenyl}benzamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-Butyl-5-methylisophthalic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-Butylsulfanyl-6-methyl-9H-1,3,4,9-tetraaza-fluorene	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162
2-Phenyldipyrrolo[1,2-a:2',1'-c]pyrazine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	Positive		162

F0108. membrane potential
F02110103. s,n-glycerophosphate shuttle
F050401. H2O2 production
F0211. transport