| Gentamicin |
5mM |
10min |
rat |
isolated rat liver (and kidney) mitochondria |
Oroboros O2K Oxygraph, complex II-based state 4 respiration |
increase |
Positive |
|
316 |
| Gentamicin |
5mM |
10min |
rat |
isolated rat liver mitochondria |
Oroboros O2K Oxygraph, complex I-based state 4 respiration |
increase |
Positive |
|
316 |
| Flufenamic Acid |
2.9 ± 0.3 |
|
rat |
isolated rat liver mitochondria |
State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) |
inhibit |
Positive |
UC50 (nmol/mg mitochondrial protein) |
40 |
| Tolfenamic Acid |
3.4 ± 0.6 |
|
rat |
isolated rat liver mitochondria |
State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) |
inhibit |
Positive |
UC50 (nmol/mg mitochondrial protein) |
40 |
| Mefenamic acid |
17.9 ± 2.2 |
|
rat |
isolated rat liver mitochondria |
State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) |
inhibit |
Positive |
UC50 (nmol/mg mitochondrial protein) |
40 |
| Meloxicam |
22.8 ± 2.8 |
|
rat |
isolated rat liver mitochondria |
State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) |
inhibit |
Positive |
UC50 (nmol/mg mitochondrial protein) |
40 |
| Sudoxicam |
37.4 ± 3.0 |
|
rat |
isolated rat liver mitochondria |
State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) |
inhibit |
Positive |
UC50 (nmol/mg mitochondrial protein) |
40 |
| Piroxicam |
69.0 ± 7.2 |
|
rat |
isolated rat liver mitochondria |
State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) |
inhibit |
Positive |
UC50 (nmol/mg mitochondrial protein) |
40 |
| Diflunisal |
6.7 ± 1.3 |
|
rat |
isolated rat liver mitochondria |
State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) |
inhibit |
Positive |
UC50 (nmol/mg mitochondrial protein) |
40 |
| Diclofenac |
56.3 ± 4.9 |
|
rat |
isolated rat liver mitochondria |
State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) |
inhibit |
Positive |
UC50 (nmol/mg mitochondrial protein) |
40 |
| Sulindac |
> 100 |
|
rat |
isolated rat liver mitochondria |
State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) |
inhibit |
Positive |
UC50 (nmol/mg mitochondrial protein) |
40 |
| Sulindac sulfide |
25.7 ± 4.5 |
|
rat |
isolated rat liver mitochondria |
State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) |
inhibit |
Positive |
UC50 (nmol/mg mitochondrial protein) |
40 |
| Nimesulide |
2.6 ± 0.2 |
|
rat |
isolated rat liver mitochondria |
State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress) |
inhibit |
Positive |
UC50 (nmol/mg mitochondrial protein) |
40 |
| buformin |
100 nmol/mg mitochondrial protein |
|
rat; Sprague–Dawley |
liver mitochondria |
Meassurement of respiration |
decrease |
Positive |
|
15 |
| Phenformin |
100 nmol/mg mitochondrial protein |
|
rat; Sprague–Dawley |
liver mitochondria |
Meassurement of respiration |
decrease |
Positive |
|
15 |
| Metformin |
500 nmol/mg mitochondrial protein |
40 minutes preincubation |
rat; Sprague–Dawley |
liver mitochondria |
Meassurement of respiration |
decrease |
Positive |
|
15 |
| buformin |
100 nmol/mg mitochondrial protein |
40 minutes preincubation |
rat; Sprague–Dawley |
liver mitochondria |
Meassurement of respiration |
decrease |
Positive |
|
15 |
| Phenformin |
100 nmol/mg mitochondrial protein |
40 minutes preincubation |
rat; Sprague–Dawley |
liver mitochondria |
Meassurement of respiration |
decrease |
Positive |
|
15 |
