Function of mitochondria >> Respiration >> Respiratory states >> state 3 respiration

Related Drugs/Compounds

Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
Perhexiline	100 μM	5 minutes preincubation	mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	193
Amiodarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Perhexiline	200 μM	5 minutes preincubation	mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	193
Perhexiline	400 μM	5 minutes preincubation	mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	193
Perhexiline	200 μM	5 minutes preincubation	mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	193
benzarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzbromarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Pioglitazone						decrease	Positive		22
benzbromarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
clomipramine						decrease	Positive		22
Chlorpromazine						decrease	Positive		22
Sulindac sulfide	39.8 ± 2.9		rat	isolated rat liver mitochondria	State 3 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress)	inhibit	Positive	IC50 (nmol/mg mitochondrial protein)	40
Miconazole	I50=100, 160, 160, 170, 150 μM for substrates Glutamate/Malate, Pyruvate/Malate, Ornithine/Malate, Arginine/Malate and Succinate repectively		rat	liver mitochondria	Clark electrode	inhibit	Positive		303
Metformin	2mM	30 minutes	mouse; C57BL/6J	isolated skeletal muscle mitochondria	Measurement of Oxygen level; incubated in complex I substrate; added ADP (500 μM)	decrease	Positive	p < 0.05	172
Nitrofurantoin	1 mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used glutamate as substrate	decrease	Positive	p < 0.05; 61% inhibition	13
Nitrofurantoin	50 μM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used glutamate as substrate	decrease	Positive	p < 0.05; 72% inhibition	13
Nitrofurantoin	5 μM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used glutamate as substrate	decrease	Positive	p < 0.05; 38% inhibition	13
Nitrofurantoin	1 mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used β-hydroxybutyrate as substrate	decrease	Positive	p < 0.05	13
Nitrofurantoin	50 μM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used β-hydroxybutyrate as substrate	decrease	Positive	p < 0.05; 60% inhibition	13
Nitrofurantoin	5 μM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used β-hydroxybutyrate as substrate	decrease	Positive	p < 0.05	13
Nitrofurantoin	1 mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used α-ketoghttarate as substrate	decrease	Positive	p < 0.05	13
Nitrofurantoin	50 μM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used α-ketoghttarate as substrate	decrease	Positive	p < 0.05; 70% inhibition	13
Nitrofurantoin	5 μM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used α-ketoghttarate as substrate	decrease	Positive	p < 0.05	13
nitrofurazone	1mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05; 64% inhibition	13
nitrofurazone	1mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05; 63% inhibition	13
Perhexiline	100 μM	5 minutes preincubation	mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05	193
Perhexiline	400 μM	5 minutes preincubation	mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	193
nitrofurazone	5μM		mouse; C57B/6J	mitoplasts	Measurement of oxygen uptake	decrease	Positive	p < 0.05	13
buformin	100 nmol/mg mitochondrial protein		rat; Sprague–Dawley	liver mitochondria	Meassurement of respiration	decrease	Positive		15
Phenformin	100 nmol/mg mitochondrial protein		rat; Sprague–Dawley	liver mitochondria	Meassurement of respiration	decrease	Positive		15
Metformin	500 nmol/mg mitochondrial protein	40 min preincubation	rat; Sprague–Dawley	liver mitochondria	Meassurement of respiration	decrease	Positive		15
buformin	100 nmol/mg mitochondrial protein	40 min preincubation	rat; Sprague–Dawley	liver mitochondria	Meassurement of respiration	decrease	Positive		15
Phenformin	100 nmol/mg mitochondrial protein	40 min preincubation	rat; Sprague–Dawley	liver mitochondria	Meassurement of respiration	decrease	Positive		15
Ketoconazole	I50=32, 74, 65, 75, 500μM for substrates Glutamate/Malate, Pyruvate/Malate, Ornithine/Malate, Arginine/Malate and Succinate repectively		rat	liver mitochondria	Clark electrode	inhibit	Positive		303