Function of mitochondria >> Respiration >> Mitochondrial parameters >> respiratory control ratio (RCR)

Related Drugs/Compounds

Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
Pioglitazone	25-50 μM		ZDF fa/fa rat & ZDF lean rat	isolated liver mitochondria	OCR and measured using a fluorescent oxygen probe (Presens)	decrease	Positive	significantly different from control (p < 0.05)	225
Amiodarone	10 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Amiodarone	20 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Amiodarone	50 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Amiodarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzbromarone	1 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzbromarone	10 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzbromarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Troglitazone	10-50 μM		ZDF fa/fa rat & ZDF lean rat	isolated liver mitochondria	OCR and measured using a fluorescent oxygen probe (Presens)	decrease	Positive	significantly different from control (p < 0.05)	225
tacrolimus	1 μM		rat	isolated kidney mitochondria	Oxygen consumption was measured with a Clark‐type electrode	decrease	Positive	10%	323
rapamycin	1 μM		rat	isolated kidney mitochondria	Oxygen consumption was measured with a Clark‐type electrode	decrease	Positive	11%	323
tacrolimus	3.4E−11 M and 2.3E−8 M		rat	isolated kidney mitochondria	Oxygen consumption was measured with a Clark‐type electrode	decrease	Positive	EC50 ; maximal inhibitory effect was about 20%	323
rapamycin	4.4×10−10 M		rat	isolated kidney mitochondria	Oxygen consumption was measured with a Clark‐type electrode	decrease	Positive	EC50 ; maximal inhibitory effect was about14%	323
2‐Butylbenzofuran	50 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05	4
2‐Butylbenzofuran	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Amiodarone	10 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Amiodarone	20 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Amiodarone	50 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Amiodarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzarone	20 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzarone	50 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Gentamicin	5mM	10min	rat	isolated rat liver (and kidney) mitochondria	Oroboros O2K Oxygraph	reduce	Positive		316
benzbromarone	0.1 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzbromarone	1 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzbromarone	10 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzbromarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
2‐Butylbenzofuran	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4